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Journal of Basic and Clinical Physiology and Pharmacology

Editor-in-Chief: Horowitz, Michal

Editorial Board: Das, Kusal K. / Epstein, Yoram / S. Gershon MD, Elliot / Haim, Abraham / Kodesh , Einat / Kohen, Ron / Lichtstein, David / Maloyan, Alina / Mechoulam, Raphael / Roth, Joachim / Schneider, Suzanne / Shohami, Esther / Sohmer, Haim / Yoshikawa, Toshikazu

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Volume 25, Issue 2


Cerebral stroke injury: the role of cytokines and brain inflammation

Antonio Siniscalchi / Luca Gallelli / Giovanni Malferrari / Domenico Pirritano / Raffaele Serra
  • Department of Medical and Surgical Science, School of Medicine, University of Catanzaro, Catanzaro, Italy
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Ermenegildo Santangelo / Giovambattista De Sarro
Published Online: 2014-02-07 | DOI: https://doi.org/10.1515/jbcpp-2013-0121


Stroke represents the most frequent cause of permanent disability in adults worldwide. Cerebral ischemia triggers the pathological pathways of the ischemic cascade and causes irreversible neuronal injury in the ischemic core within minutes of the onset. Elements of the immune system are involved in all stages of ischemic cascade from acute intravascular events triggered by the interruption of blood supply, to the parenchymal processes leading to brain damage and to the ensuing tissue repair. In this review, we will provide a brief overview of current understanding of the role of cytokines and brain inflammation during acute ischemic stroke.

Keywords: cerebral ischemia; immune system; inflammation


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About the article

Corresponding author: Luca Gallelli, Chair of Pharmacology, Department of Health Science, School of Medicine, University of Catanzaro, Clinical Pharmacology Unit, Mater Domini University Hospital, Viale Europa, Germaneto, 88100 Catanzaro, Italy, Phone: +39-0961-712322, Fax: +39-0961-774424, E-mail:

aAntonio Siniscalchi and Luca Gallelli contributed equally to this work.

Received: 2013-08-13

Accepted: 2014-01-10

Published Online: 2014-02-07

Published in Print: 2014-05-01

Citation Information: Journal of Basic and Clinical Physiology and Pharmacology, Volume 25, Issue 2, Pages 131–137, ISSN (Online) 2191-0286, ISSN (Print) 0792-6855, DOI: https://doi.org/10.1515/jbcpp-2013-0121.

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