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Journal of Basic and Clinical Physiology and Pharmacology

Editor-in-Chief: Horowitz, Michal

Editorial Board: Das, Kusal K. / Epstein, Yoram / S. Gershon MD, Elliot / Kodesh , Einat / Kohen, Ron / Lichtstein, David / Maloyan, Alina / Mechoulam, Raphael / Roth, Joachim / Schneider, Suzanne / Shohami, Esther / Sohmer, Haim / Yoshikawa, Toshikazu / Tam, Joseph

CiteScore 2016: 1.01

SCImago Journal Rank (SJR) 2016: 0.349
Source Normalized Impact per Paper (SNIP) 2016: 0.495

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Volume 26, Issue 2


Inadvertent use of bevacizumab in pregnant women with diabetes mellitus type 1

Silvio Polizzi / Giovanna Ferrara / Stefano Restaino
  • Department of Gynecology, Institute for Maternal and Child Health IRCCS Burlo Garofolo, University of Trieste, Trieste, Italy
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Silvia Rinaldi / Daniele Tognetto
Published Online: 2014-08-05 | DOI: https://doi.org/10.1515/jbcpp-2014-0058


Background: The use of vascular endothelial growth factor (VEGF) inhibitors may cause fetal harm and systemic side effects in the mother, so these drugs are contraindicated in pregnancy. We report a case of inadvertent administration of two intravitreal bevacizumab injections in a woman with diabetes mellitus type 1, 5 days before ovulation (±3 days) and during the 5th gestational week, respectively. The patient had a past history of both miscarriage and requirement for cesarean section for preeclampsia.

Methods: Observational case report.

Results: The patient did not have any drug-related adverse event and delivered a healthy full-term infant, reaching all developmental milestones appropriately during infancy.

Conclusions: Intravitreal drug injections did not result in any detectable adverse event in the mother and infant although she had a significant past obstetric history. However, there have been no studies evaluating the effects of bevacizumab in pregnant women and suggesting that intravitreal drug injection in this patient is safe. Until more is known about this, it seems reasonable to avoid treatment with this drug a few weeks before and during pregnancy.

Keywords: bevacizumab; embryo implantation intravitreal injections; preeclampsia; pregnancy; spontaneous miscarriage; VEGF


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About the article

Corresponding author: Silvio Polizzi, University Eye Clinic of Trieste – Ophthalmology, Piazza Dell’ Ospitale 1, Trieste 34129, Italy, E-mail:

Received: 2014-05-15

Accepted: 2014-06-24

Published Online: 2014-08-05

Published in Print: 2015-03-01

Citation Information: Journal of Basic and Clinical Physiology and Pharmacology, Volume 26, Issue 2, Pages 161–163, ISSN (Online) 2191-0286, ISSN (Print) 0792-6855, DOI: https://doi.org/10.1515/jbcpp-2014-0058.

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