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Journal of Basic and Clinical Physiology and Pharmacology

Editor-in-Chief: Horowitz, Michal

Editorial Board: Das, Kusal K. / Epstein, Yoram / S. Gershon MD, Elliot / Kodesh , Einat / Kohen, Ron / Lichtstein, David / Maloyan, Alina / Mechoulam, Raphael / Roth, Joachim / Schneider, Suzanne / Shohami, Esther / Sohmer, Haim / Yoshikawa, Toshikazu / Tam, Joseph


CiteScore 2016: 1.01

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2191-0286
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Volume 26, Issue 3

Issues

Role for monoaminergic systems in the antidepressant and anxiolytic properties of the hydroethanolic leaf extract from Adenia cissampeloides

Ismail O. Ishola
  • Faculty of Basic Medical Sciences, College of Medicine, Department of Pharmacology, Therapeutics and Toxicology, University of Lagos, PMB 12003 Surulere, Lagos, Nigeria
  • Other articles by this author:
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/ Sunday O. Olayemi
  • Corresponding author
  • Faculty of Basic Medical Sciences, College of Medicine, Department of Pharmacology, Therapeutics and Toxicology, University of Lagos, PMB 12003 Surulere, Lagos, Nigeria
  • Email
  • Other articles by this author:
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/ Omoniyi K. Yemitan
  • Faculty of Basic Medical Sciences, Department of Pharmacology, Lagos State University College of Medicine, Lagos, Nigeria
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/ Kolawole Akinseye
  • Faculty of Basic Medical Sciences, College of Medicine, Department of Pharmacology, Therapeutics and Toxicology, University of Lagos, PMB 12003 Surulere, Lagos, Nigeria
  • Other articles by this author:
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Published Online: 2014-08-07 | DOI: https://doi.org/10.1515/jbcpp-2014-0015

Abstract

Background: Adenia cissampeloides (Planch ex. Hook) Harms (Passifloraceae) leaf infusion is used in traditional African medicine as a stimulant to treat depression and insanity. Thus, this study investigates antidepressant and anxiolytic activities of the hydroethanol leaf extract of Adenia cissampeloides (ACE) in mice.

Methods: ACE (50–200 mg/kg, p.o.) was administered to mice 1 h before behavioral studies; the forced swimming test (FST), tail suspension test (TST), elevated-plus maze test (EPM) hole-board test (HBT) and open field test (OFT). In addition, the probable mechanisms of antidepressant- and anxiolytic-like actions of ACE were also investigated.

Results: ACE (100 and 200 mg/kg) produced significant (p<0.01) reduction in immobility, along with a significant increase in swimming activity (75.20%) and climbing (190.00%), respectively, similar to anti-immobility effect of imipramine in the FST. Also, in TST, ACE (100 and 200 mg/kg) treatment significantly (p<0.01) reduced the immobility time by 35.60%, and 35.27%, respectively, which was similar to anti-immobility effect of fluoxetine (32.50%). However, the antidepressant-like effect produced by ACE was prevented (p<0.01) by yohimbine (α2-adrenoceptor antagonist), or sulpiride (dopamine D2 receptor antagonist) pretreatment. ACE (50 and 100 mg/kg) treatment (p<0.01) increased number (41.67%) and duration of head-dips (52.27%) in HBT. Similarly, ACE (50–200 mg/kg) increased duration of open arm entries (p<0.001) in EPM. However, this effect was reversed (p<0.001) by pretreatment of mice with cyproheptadine (5-HT2 receptor antagonist) (60.87%).

Conclusions: Findings from these studies revealed antidepressant-like effect of ACE mediated through interaction with dopamine D2- receptor or α2-adrenoceptor. Also an anxiolytic-like effect through interaction with 5-HT2 receptors.

Keywords: Adenia cissampeloide; α2 -adrenoceptor; dopamine D2 receptor; elevated plus maze test, 5-HT2 receptor; forced swimming test

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About the article

Corresponding author: Sunday O. Olayemi, Faculty of Basic Medical Sciences, College of Medicine, Department of Pharmacology, Therapeutics and Toxicology, University of Lagos, PMB 12003 Surulere, Lagos, Nigeria, Mobile: +2348023150200, E-mail:


Received: 2014-02-17

Accepted: 2014-06-22

Published Online: 2014-08-07

Published in Print: 2015-05-01


Citation Information: Journal of Basic and Clinical Physiology and Pharmacology, Volume 26, Issue 3, Pages 301–312, ISSN (Online) 2191-0286, ISSN (Print) 0792-6855, DOI: https://doi.org/10.1515/jbcpp-2014-0015.

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