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Journal of Basic and Clinical Physiology and Pharmacology

Editor-in-Chief: Horowitz, Michal

Editorial Board: Das, Kusal K. / Epstein, Yoram / S. Gershon MD, Elliot / Kodesh , Einat / Kohen, Ron / Lichtstein, David / Maloyan, Alina / Mechoulam, Raphael / Roth, Joachim / Schneider, Suzanne / Shohami, Esther / Sohmer, Haim / Yoshikawa, Toshikazu / Tam, Joseph


CiteScore 2016: 1.01

SCImago Journal Rank (SJR) 2016: 0.349
Source Normalized Impact per Paper (SNIP) 2016: 0.495

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2191-0286
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Volume 26, Issue 3

Issues

Acute high blood glucose level attenuates histamine-stimulated acid secretion in male Wistar rats

Taofeek O. Usman / Lawrence A. Olatunji
  • Department of Physiology, College of Health Sciences, University of Ilorin, Ilorin, Nigeria
  • Cardiovascular Research Institute and Department of Pharmacology, Kyungpook National University School of Medicine, Daegu, Republic of Korea
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Abdul Rasak A. Alada
Published Online: 2014-12-03 | DOI: https://doi.org/10.1515/jbcpp-2014-0022

Abstract

Background: Studies have shown that the hyperglycemic state induced by intravenous glucagon or glucose infusion may lead to inhibition of gastric acid secretion through the inhibition of gastric vagus activity. Histamine is a well-known mammalian acid secretagogue and it stimulates acid secretion through H2 receptors. Therefore, the aim of this study was to determine what effect an acute hyperglycemic or hypoglycemic state would have on histamine-stimulated acid secretion.

Methods: Male Wistar rats weighing between 200 and 250 g were divided into three groups that received an intravenous infusion of normal saline (control group), glucose (hyperglycemic group), or insulin (hypoglycemic group) followed by injection of histamine to stimulate acid secretion. The oesophageal and duodenal ends of the rats’ stomach were cannulated with polythene tubing and the stomach was perfused at room temperature using a Langendoff perfusion apparatus. The effluent was collected in aliquots over 10 min per sample and its pH was measured.

Results: There was a significant (p<0.05) decrease in acid secretion following histamine injection in the hyperglycemic rats, while histamine injection led to an increase (p<0.05) in acid secretion in the hypoglycemic rats.

Conclusions: These results show that hyperglycemic state would result in attenuated histamine-stimulated gastric acid secretion, while hypoglycemic state would lead to increased histamine-stimulated gastric acid secretion.

Keywords: acid secretion; histamine; hyperglycemia; hypoglycemia; insulin

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About the article

Corresponding author: Taofeek O. Usman, Department of Physiology, College of Health Sciences, University of Ilorin. P.M.B. 1515 Ilorin Kwara State, Nigeria, Phone: +2348068449324, E-mail:


Received: 2014-03-05

Accepted: 2014-08-16

Published Online: 2014-12-03

Published in Print: 2015-05-01


Citation Information: Journal of Basic and Clinical Physiology and Pharmacology, Volume 26, Issue 3, Pages 259–263, ISSN (Online) 2191-0286, ISSN (Print) 0792-6855, DOI: https://doi.org/10.1515/jbcpp-2014-0022.

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