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Journal of Basic and Clinical Physiology and Pharmacology

Editor-in-Chief: Horowitz, Michal

Editorial Board: Das, Kusal K. / Epstein, Yoram / S. Gershon MD, Elliot / Kodesh , Einat / Kohen, Ron / Lichtstein, David / Maloyan, Alina / Mechoulam, Raphael / Roth, Joachim / Schneider, Suzanne / Shohami, Esther / Sohmer, Haim / Yoshikawa, Toshikazu / Tam, Joseph


CiteScore 2016: 1.01

SCImago Journal Rank (SJR) 2016: 0.349
Source Normalized Impact per Paper (SNIP) 2016: 0.495

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2191-0286
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Volume 26, Issue 5

Issues

Analgesic and anti-inflammatory activity of Tectona grandis Linn. stem extract

Sapna P. Giri
  • Corresponding author
  • Deparment of Pharmacology, JIIU’S Indian Institute of Medical Science & Research, Warudi, Badnapur, Jalna, Maharashtra, India
  • Email
  • Other articles by this author:
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/ Sushilkumar B. Varma
Published Online: 2015-04-22 | DOI: https://doi.org/10.1515/jbcpp-2014-0043

Abstract

Background: The objective of this work was to study the analgesic and anti-inflammatory activity of Tectona grandis Linn. (TG) stem extract.

Methods: Healthy albino rats (150–200 g) and mice (25–50 g) were arranged and divided into five groups. Group 1 received distilled water and served as control, groups 2, 3, 4 were treated with TG stem extract (100, 200, 400 mg/kg) and group 5 received standard drug. For analgesic activity, the radiant heat method and writhing test were used, and for anti-inflammatory activity, the paw oedema model and granuloma pouch method were used. Statistical analysis was done by one-way analysis of variance followed by the t-test.

Results: In the radiant heat method, there was a dose-dependent increase in reaction time in TG stem extract (100, 200, 400 mg/kg) and standard drug (buprenorphine). In the writhing test, TG stem extract (200, 400 mg/kg) and aspirin decreased the number of writhes which was significant (p<0.01, p<0.001) as compared to controls. The percentage protection was 8.88%, 15.55%, 22.22% and 35.55% in groups 2, 3, 4 and 5, respectively. In the rat paw oedema test, TG stem extract (200, 400 mg/kg) and aspirin showed 20%, 40% and 54% inhibition of oedema which was statistically significant (p<0.05, p<0.01, p<0.001), respectively, as compared to control at the end of 4 h. In the granuloma pouch method, TG stem extract (100, 200, 400 mg/kg) and aspirin showed 13.33%, 22.22%, 33.33% and 66.66% inhibition of granuloma, respectively, which was significant (p<0.05, p<0.01, p<0.001).

Conclusions: TG stem extract possesses significant anti-inflammatory and analgesic activity.

Keywords: analgesic activity; anti-inflammatory activity; carrageenan-induced paw oedema and cotton pellet-induced granuloma; hydro-alcoholic stem extract; radiant heat method; Tectona grandis Linn.; writhing test

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About the article

Corresponding author: Dr. Sapna P. Giri, C/O Deepak N. Puri, Ashiyad Colony, Shegaon road, Amravati-444602, Maharashtra, India, E-mail: ; and Deparment of Pharmacology, JIIU’S Indian Institute of Medical Science & Research, Warudi, Badnapur, Jalna, Maharashtra, India


Received: 2014-04-05

Accepted: 2015-03-19

Published Online: 2015-04-22

Published in Print: 2015-09-01


Citation Information: Journal of Basic and Clinical Physiology and Pharmacology, Volume 26, Issue 5, Pages 479–484, ISSN (Online) 2191-0286, ISSN (Print) 0792-6855, DOI: https://doi.org/10.1515/jbcpp-2014-0043.

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