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Journal of Basic and Clinical Physiology and Pharmacology

Editor-in-Chief: Horowitz, Michal

Editorial Board: Das, Kusal K. / Epstein, Yoram / S. Gershon MD, Elliot / Haim, Abraham / Kodesh , Einat / Kohen, Ron / Lichtstein, David / Maloyan, Alina / Mechoulam, Raphael / Roth, Joachim / Schneider, Suzanne / Shohami, Esther / Sohmer, Haim / Yoshikawa, Toshikazu

6 Issues per year


CiteScore 2016: 1.01

SCImago Journal Rank (SJR) 2016: 0.349
Source Normalized Impact per Paper (SNIP) 2016: 0.495

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2191-0286
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Volume 26, Issue 6

Issues

Prevalence of cardiovascular risk factors and management practices of acute coronary syndrome in a tertiary care hospital

Chandrasekhar Dilip
  • Corresponding author
  • Department of Pharmacy Practice, Al Shifa College of Pharmacy, Poonthavanam, Kizhattur, Perinthalmanna, Kerala, India
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/ Shinu Cholamugath
  • Department of Pharmacy Practice, Al Shifa College of Pharmacy, Poonthavanam, Kizhattur, Perinthalmanna, Kerala, India
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/ Molniya Baby
  • Department of Pharmacy Practice, Al Shifa College of Pharmacy, Poonthavanam, Kizhattur, Perinthalmanna, Kerala, India
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/ Danisha Pattani
  • Department of Pharmacy Practice, Al Shifa College of Pharmacy, Poonthavanam, Kizhattur, Perinthalmanna, Kerala, India
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Published Online: 2015-08-15 | DOI: https://doi.org/10.1515/jbcpp-2014-0055

Abstract

Background: A prospective study of patients with acute coronary syndrome (ACS), who met the inclusion criteria, was carried out. It was conducted in the cardiology department of tertiary care referral hospital in Kerala. An attempt was made to identify and determine the prevalence of cardiovascular risk factors in patients presenting with ACS and to evaluate the current treatment practice pattern of ACS and to compare it with standard treatment guidelines, thereby improving the quality of life of patients.

Methods: Data of patients who met the inclusion criteria were collected in specially designed data collection form. The form included the patient data such as demographics, risk factors, procedures performed during the hospital stay, and in-hospital and discharge drug therapy. Patients with ACS included those with ST-elevation myocardial infarction (STEMI), non-ST elevation myocardial infarction (NSTEMI), and unstable angina (UA). Descriptive statistics were performed. All statistical analysis was done using Statistical Package for Social Sciences (SPSS) software version 16.0.

Results: A total of 100 patients were studied having mean age of 62.57 years±12.18 years. Fifty-one percent were having NSTEMI, 33% were having STEMI, and 16% were having UA. Hypertension (63%) and diabetes (51%) were more prevalent in both men and women. Smoking among males was consistently high (48.6%), being highest among adults. Cardiac procedures performed include percutaneous transluminal coronary angioplasty (PTCA) in 45%, coronary angiogram (CAG) in 20%, and coronary artery bypass graft surgery (CABG) in 7%. In-hospital medications were antiplatelets (100%), thrombolytics (28%), statins (97%), anticoagulants (80%), nitrates (73%), β-blocker (32%), angiotensin-converting enzyme inhibitor (6%), angiotensin receptor blocker (9%), potassium opener (7%), vasodilator (1%), calcium channel blocker (9%), α-blocker (7%), and α+β blocker (7%).

Conclusions: The contemporary profile of treatment patterns for patients with ACS indicates an improved adherence to the guidelines. The alarmingly high rate of modifiable risk factors remains a cause of concern and a challenge that needs to be tackled, as better control of cardiovascular risk factors is expected to have a favorable impact on the incidence of ACS.

Keywords: acute coronary syndrome; coronary artery disease; risk factors; treatment pattern

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About the article

Corresponding author: Dr. Chandrasekhar Dilip, Professor and Head, Department of Pharmacy Practice, Al Shifa College of Pharmacy, Poonthavanam P.O, Perinthalmanna – 679325, Kerala, India, E-mail:


Received: 2014-05-02

Accepted: 2015-04-25

Published Online: 2015-08-15

Published in Print: 2015-11-01


Citation Information: Journal of Basic and Clinical Physiology and Pharmacology, Volume 26, Issue 6, Pages 547–554, ISSN (Online) 2191-0286, ISSN (Print) 0792-6855, DOI: https://doi.org/10.1515/jbcpp-2014-0055.

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