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Journal of Basic and Clinical Physiology and Pharmacology

Editor-in-Chief: Horowitz, Michal

Editorial Board Member: Das, Kusal K. / Epstein, Yoram / S. Gershon MD, Elliot / Haim, Abraham / Kodesh , Einat / Kohen, Ron / Lichtstein, David / Maloyan, Alina / Mechoulam, Raphael / Roth, Joachim / Schneider, Suzanne / Shohami, Esther / Sohmer, Haim / Yoshikawa, Toshikazu

6 Issues per year


CiteScore 2016: 1.01

SCImago Journal Rank (SJR) 2016: 0.349
Source Normalized Impact per Paper (SNIP) 2016: 0.495

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2191-0286
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Volume 26, Issue 6 (Nov 2015)

Issues

Neurobehavioural evaluation of Lophira alata (Ochnaceae) stem bark extract in mice

Loretta O. Iniaghe / Igbe Ighodaro / Mohammed G. Magaji / Tabot P. Tabot / Ijeoma T. Maduka
Published Online: 2015-03-14 | DOI: https://doi.org/10.1515/jbcpp-2014-0096

Abstract

Background: Stem bark and leaves of Lophira alata (Family: Ochnaceae) have been used traditionally for their anti-psychotic, anti-convulsant and anxiolytic properties. Since no existing data was found on the neurobehavioural properties, this study was carried out to evaluate some neurobehavioural properties of the aqueous extract of the stem bark of L. alata in animal models.

Methods: The oral mean lethal dose (LD50) of the extract was estimated, and preliminary phytochemical screening was conducted. Lophira alata extract (200, 400 and 800 mg/kg, p.o.) was investigated for antidepressant effect using the forced swim and tail suspension tests, and the anxiolytic potential was assessed using the stair case and hole board tests. Pentylenetetrazole-induced convulsion test was used to investigate the anticonvulsant potential of the extract.

Results: The LD50 was estimated to be >5000 mg/kg. Oral administration of L. alata extract produced a significant (p<0.05) non-dose-dependent decrease in the period of immobility in both the forced swim and tail suspension tests. While a significant decrease (p<0.05) in episodes of grooming was recorded in the staircase test, the number of head dips was not significantly reduced (p>0.05) in the hole board test. In the pentylenetetrazole-induced convulsion, a non-dose-dependent increase in onset of tonic-clonic seizures and protection from death was recorded.

Conclusions: The results obtained suggest that the aqueous stem bark extract of L. alata possesses neurobehavioural properties which may account for its use in ethnomedicine.

Keywords: anxiolysis; convulsion; depression; ethnomedicine; L ophira alata

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About the article

Corresponding author: Loretta O. Iniaghe, 24570 Stewart Street, 65c, Loma Linda, CA 92354, CA, USA, Phone: +14142080319, +2348022113816, E-mail: ; and Department of Pharmacology and Toxicology, University of Benin, Benin City, Nigeria


Received: 2014-08-25

Accepted: 2015-01-05

Published Online: 2015-03-14

Published in Print: 2015-11-01


Citation Information: Journal of Basic and Clinical Physiology and Pharmacology, ISSN (Online) 2191-0286, ISSN (Print) 0792-6855, DOI: https://doi.org/10.1515/jbcpp-2014-0096.

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