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Journal of Basic and Clinical Physiology and Pharmacology

Editor-in-Chief: Horowitz, Michal

Editorial Board: Das, Kusal K. / Epstein, Yoram / S. Gershon MD, Elliot / Haim, Abraham / Kodesh , Einat / Kohen, Ron / Lichtstein, David / Maloyan, Alina / Mechoulam, Raphael / Roth, Joachim / Schneider, Suzanne / Shohami, Esther / Sohmer, Haim / Yoshikawa, Toshikazu

CiteScore 2016: 1.01

SCImago Journal Rank (SJR) 2016: 0.349
Source Normalized Impact per Paper (SNIP) 2016: 0.495

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Volume 29, Issue 2


Antidiarrheal and antimicrobial activities of the ethanol extract from the Icacina senegalensis root bark

Godwin C. Akuodor
  • Corresponding author
  • Department of Pharmacology and Therapeutics, Faculty of Medicine, Ebonyi State University, Abakaliki, Nigeria, Phone: +2348036725237,
  • Email
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/ Ndubuisi N. Nwobodo
  • Department of Pharmacology and Therapeutics, Faculty of Medicine, Ebonyi State University, Abakaliki, Nigeria
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/ Anthony U. Megwas
  • Department of Optometry, School of Health Technology, Federal University of Technology, Owerri, Nigeria
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/ Joseph L. Akpan
  • Department of Pharmacology and Therapeutics, Faculty of Medicine, Ebonyi State University, Abakaliki, Nigeria
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/ Daniel C. Nwachukwu
  • Department of Physiology, College of Medicine, University of Nigeria, Enugu Campus, Nsukka, Nigeria
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/ Ebere C. Asika
  • Department of Pharmacology and Therapeutics, Faculty of Medicine, Ebonyi State University, Abakaliki, Nigeria
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/ Kingsley C. Chilaka
  • Department of Pharmacology and Therapeutics, College of Health Sciences, Nnamdi Azikiwe University, Awka, Nigeria
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Published Online: 2017-11-25 | DOI: https://doi.org/10.1515/jbcpp-2016-0174



The Icacina senegalensis root bark is traditionally used for the treatment of gastrointestinal disorders in Nigeria. To date, no scientific study has substantiated or refuted this claim.


The antidiarrheal and antimicrobial activities of the ethanol root bark extract were investigated in rats and against some selected diarrhea-causing microorganisms.


The extract significantly decreased the frequency of castor oil-induced diarrhea, and inhibited the masses and volumes of intestinal fluid accumulation in the castor oil-induced enteropooling method. The distance travelled by the charcoal meal was also decreased by the extract gastrointestinal transit method. The extract also strongly inhibited the growth of some selected microorganisms.


The ethanol extract of the I. senegalensis root bark showed antidiarrheal activity, thus justifying its long folkloric use in diarrhea treatment. The extract also demonstrated antimicrobial activity against selected diarrheal causing organisms.

Keywords: antidiarrheal; antimicrobial; castor oil; Icacina senegalensis; root bark


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About the article

Received: 2016-10-26

Accepted: 2017-10-25

Published Online: 2017-11-25

Published in Print: 2018-03-28

Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved its submission.

Research funding: None declared.

Employment or leadership: None declared.

Honorarium: None declared.

Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.

Citation Information: Journal of Basic and Clinical Physiology and Pharmacology, Volume 29, Issue 2, Pages 211–216, ISSN (Online) 2191-0286, ISSN (Print) 0792-6855, DOI: https://doi.org/10.1515/jbcpp-2016-0174.

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