Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Journal of Basic and Clinical Physiology and Pharmacology

Editor-in-Chief: Horowitz, Michal

Editorial Board: Das, Kusal K. / Epstein, Yoram / S. Gershon MD, Elliot / Kodesh , Einat / Kohen, Ron / Lichtstein, David / Maloyan, Alina / Mechoulam, Raphael / Roth, Joachim / Schneider, Suzanne / Shohami, Esther / Sohmer, Haim / Yoshikawa, Toshikazu / Tam, Joseph


CiteScore 2016: 1.01

SCImago Journal Rank (SJR) 2016: 0.349
Source Normalized Impact per Paper (SNIP) 2016: 0.495

Online
ISSN
2191-0286
See all formats and pricing
More options …
Volume 30, Issue 3

Issues

The protective effect of aqueous extract of Typha capensis rhizomes on cadmium-induced infertility in rats

Mavuto Masopera Gondwe / Andile Mpungose / Davie Rexon Kamadyaapa / Mathulo Shauli / Eugene Ndebia / Constance Sewani-Rusike / Jehu Iputo / Adebola Oyedeji
Published Online: 2019-05-04 | DOI: https://doi.org/10.1515/jbcpp-2018-0173

Abstract

Background

Typha capensis is one of the medicinal plants commonly used to manage male fertility problems. The objective of the present study was to assess its fertility-promoting effects in a rat model of cadmium-induced infertility.

Methods

A total of 30 male Wister rats were randomly divided into five groups of six animals each. Animals of group I, which served as control, were administered with cadmium chloride (CdCl2; 2.5 mg/kg) and normal saline (2 mL/kg). Group II was served with 0.5 mL normal saline only. Animals of groups III–V were treated with CdCl2 (2.5 mg/kg) plus T. capensis extract at doses of 100, 200, and 400 mg/kg, respectively. Animals were sacrificed under sedation. Testes and epididymal weights and sperm count were determined. Histological assessment of the testes was conducted.

Results

T. capensis at any dose did not improve (p > 0.05) testicular and epididymal weights compared with those of the CdCl2-exposed control group. Histology revealed moderate necrosis in the same group. T. capensis modestly increased the sperm count by 14%, 31%, and 35%, for groups treated with the extract at doses 100, 200, and 400 mg/kg, respectively, when compared with the CdCl2 control group, although the differences were not significant statistically (p > 0.05).

Conclusions

Results of our study demonstrated that T. capensis can neither offer protective effects against oxidative stress nor promote fertility in an animal model of cadmium-induced infertility.

Keywords: cadmium chloride; male infertility; reproductive health; Typha capensis

References

  • [1]

    Sharlip ID, Jarow JP, Belker AM, Lipshultz LI, Sigman M, Thomas AJ, et al. Best practice policies for male infertility. Fertil Steril 2002;77:873–82.CrossrefPubMedGoogle Scholar

  • [2]

    Poongothai J, Gopenath TS, Manonayaki S. Genetics of human male infertility. Singapore Med J 2009;50:336–47.PubMedGoogle Scholar

  • [3]

    Gerrits T, Shaw M. Biomedical infertility care in sub-Saharan Africa: a social science review of current practices, experiences and viewpoints. Facts Views Vis ObGYn 2010;2:194–207.Google Scholar

  • [4]

    Zegers-Hochschild F, Adamson GD, de Mouzon J, Ishihara O, Mansour R. The International Committee for Monitoring Assisted Reproductive Technology (ICMART) and the World Health Organization (WHO) revised glossary on ART terminology. Hum Reprod 2009;24:2683–7.Web of ScienceCrossrefPubMedGoogle Scholar

  • [5]

    Karapanou O, Papadimitriou A. Determinants of menarche. Reprod Biol Endocrinol 2010;8:115. Available at: http://www.rbej.com/content/8/1/115.CrossrefWeb of SciencePubMed

  • [6]

    Lin Q, Sirotkin A, Skoultchi AL. Normal spermatogenesis in mice lacking the testis-specific linker histone H1t. Mol Cell Biol 2000;20:2122–8.PubMedCrossrefGoogle Scholar

  • [7]

    Ige SF, Olaleye SB, Akhigbe RE, Akanbi TA, Oyekunle OA, Udoh UA. Testicular toxicity and sperm quality following cadmium exposure in rats: ameliorative potentials of Allium cepa. J Human Reprod Sci 2012;5:37–42.CrossrefGoogle Scholar

  • [8]

    Asadi M, Zafari F, Sarveazad A, Abbasi M, Safa M, Koruji M, et al. Saffron improves epididymal sperm parameters in rats exposed to cadmium. Nephrourol Mon 2014;6:e12125.PubMedGoogle Scholar

  • [9]

    Belsey MA. The epidemiology of infertility: a review with particular reference to sub-Saharan Africa. Bull World Health Organ 1976;54:319–41.PubMedGoogle Scholar

  • [10]

    Ombelet W, Cooke I, Dyer S, Serour G, Devroey P. Infertility and the provision of infertility medical services in developing countries. Hum Reprod Update 2008;14:605–21.CrossrefPubMedWeb of ScienceGoogle Scholar

  • [11]

    Chachamovich JR, Chachamovich E, Ezer H, Fleck MP, Knauth D, Passos E. Investigating quality of life and health-related quality of life in infertility: a systematic review. J Psychosom Obstet Gynaecol 2010;31:101–10.PubMedCrossrefGoogle Scholar

  • [12]

    Boivin J, Bunting L, Collins JA, Nygren KG. International estimates of infertility prevalence and treatment-seeking: potential need and demand for infertility medical care. Hum Reprod 2007;22:1506–12.CrossrefPubMedGoogle Scholar

  • [13]

    Richardson MA, Sanders T, Palmer JL, Greisinger A, Singletary SE. Complementary/alternative medicine use in a comprehensive cancer centre and the implications of oncology. J Clin Oncol 2000;18:2505–14.CrossrefGoogle Scholar

  • [14]

    Sewani-Rusike C, Iputo J, Ndebia E, Gondwe M, Kamadyaapa D. A comparative study on the aphrodisiac activity of food plants Mondia whitei, Chenopodium album, Cucurbita pepo and Sclerocarya birrea extracts in male Wistar rats. Afr J Tradit Complement Altern Med 2015;12:22–6.CrossrefGoogle Scholar

  • [15]

    Abdel-Magied EM, Abdel-Rahman HA, Harraz FM. The effect of aqueous extracts of Cynomorium coccineum and Withania somnifera on testicular development in immature Wistar rats. J Ethnopharmacol 2001;75:1–4.CrossrefPubMedGoogle Scholar

  • [16]

    Rahman T, Hosen I, Islam M, Shekhar H. Oxidative stress and human health. Adv Biosci Biotechnol 2012;3:997–1019.CrossrefGoogle Scholar

  • [17]

    Abbasi M, Dadkhah N, Shahnazi M, Parvin N. Protective effects of Melissa officinalis (Lemon Balm) on sperm parameters and spermatogenesis quality in rats exposed to lead. Iran Red Crescent Med J 2016;18:e31798.Web of ScienceGoogle Scholar

  • [18]

    Sayed M, Hassanein K, Senosy W. Protective effects of thymoquinone and l-cysteine on cadmium-induced reproductive toxicity in rats. Toxicol Rep 2014;1:612–20.PubMedCrossrefGoogle Scholar

  • [19]

    Siu ER, Mruk D, Porto CS, Cheng C. Cadmium induced testicular injury. Toxicol Appl Pharmacol 2009;238:240–9.PubMedCrossrefWeb of ScienceGoogle Scholar

  • [20]

    Kusakabe T, Nakajima K, Suzuki K, Nakazato K, Takada H, Satoh T, et al. The changes of heavy metal and metallothionein distribution in testis induced by cadmium exposure. Biometals 2008;21:71–81.CrossrefWeb of SciencePubMedGoogle Scholar

  • [21]

    Antolovich M, Prenzler PD, Patsalides E, McDonald S, Robards K. Methods for testing antioxidant activity. Analyst 2002;127:183–98 [Review Erratum: Analyst 2002;127:430].CrossrefPubMedGoogle Scholar

  • [22]

    Henkel R, Fransman W, Hipler UC, Wiegand C, Schreiber G, Menkveld R, et al. Typha capensis (Rohrb) N.E.Br (bulrush) extract scavenges free radicals, inhibits collagenase activity and affects human sperm motility and mitochondrial membrane potential in vitro: a pilot study. Andrologia 2012;44:287–94.CrossrefPubMedWeb of ScienceGoogle Scholar

  • [23]

    Kooti W, Mansouri E, Ghasemiboroon M, Harizi M, Ashtary-Larky D, Afrisham R. The effects of hydroalcoholic extract of Apium graveolens leaf on the number of sexual cells and testicular structure in rat. Jundishapur J Nat Pharm Prod 2014;9:e17532.PubMedGoogle Scholar

About the article

Received: 2018-09-23

Accepted: 2019-01-19

Published Online: 2019-05-04


Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

Research funding: None declared.

Employment or leadership: None declared.

Honorarium: None declared.

Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.


Citation Information: Journal of Basic and Clinical Physiology and Pharmacology, Volume 30, Issue 3, 20180173, ISSN (Online) 2191-0286, DOI: https://doi.org/10.1515/jbcpp-2018-0173.

Export Citation

©2019 Walter de Gruyter GmbH, Berlin/Boston.Get Permission

Comments (0)

Please log in or register to comment.
Log in