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Journal of Complementary and Integrative Medicine

Editor-in-Chief: Lui, Edmund

Ed. by Ko, Robert / Leung, Kelvin Sze-Yin / Saunders, Paul / Suntres, PH. D., Zacharias


CiteScore 2017: 1.41

SCImago Journal Rank (SJR) 2017: 0.472
Source Normalized Impact per Paper (SNIP) 2017: 0.564

Online
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1553-3840
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Pharmacological Evaluation of Fruits of Terminalia belerica Roxb. for Antiulcer Activity

Hitesh Jawanjal / Mithun S. Rajput / Purti Agrawal / Vikramsingh Dange
Published Online: 2012-06-18 | DOI: https://doi.org/10.1515/1553-3840.1556

The antiulcer activity of 70% methanolic extract of fruits of Terminalia belerica Roxb. (Combretaceae) was evaluated using ethanol induced, aspirin induced, cold stress restraint and pylorus ligated ulcer in rats. The methanolic extract (100, 250, 500, 1000 mg/kg, p.o.) significantly suppressed the peptic ulcer induced by ethanol. Methanolic extract at a dose of 500 mg/kg showed, promising antiulcer activity hence, this dose was selected for further evaluation of antiulcer studies. The methanolic extract (500 mg/kg) showed significant (p<0.05) reduction in gastric volume, free acidity, total acidity, ulcer index, protein and pepsin content and increase in mucus content in pylorus ligated rats as compared to control. Treatment with Terminalia belerica methanolic extract further provided significant antiulcer protection against aspirin induced ulcers but not in cold stress restraint model. These results suggested that the 70% methanolic extract of Terminalia belerica increased resistance to necrotizing agents, providing a direct protective effect on the gastric mucosa and exhibited antiulcer effect.

Keywords: aspirin induced; ethanol induced; cold restraint; pylorus ligation; antiulcer; Terminalia belerica

About the article

Published Online: 2012-06-18


Citation Information: Journal of Complementary and Integrative Medicine, Volume 9, Issue 1, ISSN (Online) 1553-3840, DOI: https://doi.org/10.1515/1553-3840.1556.

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