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Journal of Complementary and Integrative Medicine

Editor-in-Chief: Lui, Edmund

Ed. by Ko, Robert / Leung, Kelvin Sze-Yin / Saunders, Paul / Suntres, PH. D., Zacharias

CiteScore 2017: 1.41

SCImago Journal Rank (SJR) 2017: 0.472
Source Normalized Impact per Paper (SNIP) 2017: 0.564

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Antioxidant Potential and Protection of Pancreatic ?- cells by Calotropis gigantea in Streptozocin Induced Diabetic Rats

Naveen Kumar Choudhary / Swapnil Sharma / A. K. Jha / Manvendra Singh Karchuli / Jaya Dwivedi
Published Online: 2012-05-10 | DOI: https://doi.org/10.1515/1553-3840.1562

This study was designed to examine the antioxidant defense by chloroform extract of Calotropis gigantea on streptozotocin-(40mg/kg, intraperitonial, single-injection) induced diabetes in wistar albino rats. The extract significantly (P < .05) decreased the pancreatic thiobarbituric acid-reactive substances (TBARS) levels and significantly (P < .05) increased the superoxide dismutase, catalase, and glutathione levels as compared to above levels in pancreatic tissue of pathogenic diabetic rats. The results of test drug were comparable to Glibenclamide (5mg/kg, daily), a standard antihyperglycemic agent. The study concludes that Calotropis gigantea enhances the antioxidant defense against reactive oxygen species produced under hyperglycemic condition and this protects β-cells against loss, and exhibit antidiabetic property.

Keywords: antioxidant; Calotropis gigantea; streptozotocin; diabetes; β-cells; glibenclamide

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Published Online: 2012-05-10

Citation Information: Journal of Complementary and Integrative Medicine, Volume 9, Issue 1, ISSN (Online) 1553-3840, DOI: https://doi.org/10.1515/1553-3840.1562.

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©2012 Walter de Gruyter GmbH & Co. KG, Berlin/Boston.Get Permission

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