Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Journal of Complementary and Integrative Medicine

Editor-in-Chief: Lui, Edmund

Ed. by Ko, Robert / Leung, Kelvin Sze-Yin / Saunders, Paul / Suntres, PH. D., Zacharias

CiteScore 2017: 1.41

SCImago Journal Rank (SJR) 2017: 0.472
Source Normalized Impact per Paper (SNIP) 2017: 0.564

See all formats and pricing
More options …

Potentiation of Etoposide and Temozolomide Cytotoxicity by Curcumin and Turmeric Force in Brain Tumor Cell Lines

Cheppail Ramachandran / Smitha M. Nair / Enrique Escalon / Steven J. Melnick
Published Online: 2012-08-10 | DOI: https://doi.org/10.1515/1553-3840.1614


We have investigated on the potentiation of etoposide (ETP) and temozolomide (TMZ) cytotoxicity in U-87MG glioblastoma and D283 medulloblastoma cell lines by curcumin (CUR) and turmeric force (TF), a nutraceutical formulation of turmeric, with the objective of assessing the potential for their adjuvant use in brain tumor chemotherapy. While U-87MG cell line was generally resistant to TMZ, IC50 values for CUR and TF were 37.33 and 30.75 µg/ml, respectively. TF is the only agent that demonstrated efficacy at the IC90 level. When CUR or TF was combined with ETP and TMZ, increased chemotherapeutic efficiency in the U-87MG cells was observed. TF is highly cytotoxic to D283 Med cell line compared to curcumin with an IC50 value of 1.55 ug/ml. Although both CUR and TF potentiated ETP and TMZ cytotoxicity, TF is more efficient than CUR in both U-87MG and D283 Med cell lines. Treatment of U-87MG cells with the triple combination of TMZ+ETP+TF induced a high percentage of apoptotic cells. Potential mechanisms that may explain evidence of synergy include down regulation of p10 and p53 mRNAs and increase in BAX/Bcl-2 mRNA ratio. These pre-clinical results suggest that TF may be useful as an adjuvant with ETP and TMZ for brain tumor chemotherapy.

Keywords: Glioblastoma multiforme; etoposide; temozolomide; curcumin; turmeric force; apoptosis; synergism; gene expression

About the article

Published Online: 2012-08-10

Citation Information: Journal of Complementary and Integrative Medicine, Volume 9, Issue 1, ISSN (Online) 1553-3840, DOI: https://doi.org/10.1515/1553-3840.1614.

Export Citation

©2012 Walter de Gruyter GmbH & Co. KG, Berlin/Boston.Get Permission

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Fratantonio Deborah, Molonia Maria Sofia, Bashllari Romina, Muscarà Claudia, Ferlazzo Guido, Costa Gregorio, Saija Antonella, Cimino Francesco, and Speciale Antonio
Phytomedicine, 2018
Cheppail Ramachandran, Karl-Werner Quirin, Enrique Escalon, and Steven J. Melnick
Journal of Evidence-Based Complementary & Alternative Medicine, 2014, Volume 19, Number 2, Page 119
Cheppail Ramachandran, Ivonne V. Lollett, Enrique Escalon, Karl-Werner Quirin, and Steven J. Melnick
Journal of Evidence-Based Complementary & Alternative Medicine, 2015, Volume 20, Number 2, Page 109
Oncology Reports, 2014, Volume 32, Number 4, Page 1610
Gregor A. Rodriguez, Ashish H. Shah, Zachary C. Gersey, Sumedh S. Shah, Amade Bregy, Ricardo J. Komotar, and Regina M. Graham
Therapeutic Advances in Medical Oncology, 2016, Volume 8, Number 4, Page 248
Cheppail Ramachandran, Smitha M. Nair, Karl-W. Quirrin, and Steven J. Melnick
Journal of Evidence-Based Complementary & Alternative Medicine, 2013, Volume 18, Number 4, Page 248
Neil V. Klinger and Sandeep Mittal
Oxidative Medicine and Cellular Longevity, 2016, Volume 2016, Page 1
Sylvie Lamy, Aroua Ben Saad, Alain Zgheib, and Borhane Annabi
The Journal of Nutritional Biochemistry, 2016, Volume 27, Page 136
Cheppail Ramachandran, Karl-W. Quirin, Enrique A. Escalon, Ivonne V. Lollett, and Steven J. Melnick
Phytotherapy Research, 2015, Volume 29, Number 8, Page 1152

Comments (0)

Please log in or register to comment.
Log in