Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Journal of Complementary and Integrative Medicine

Editor-in-Chief: Lui, Edmund

Ed. by Ko, Robert / Leung, Kelvin Sze-Yin / Saunders, Paul / Suntres, PH. D., Zacharias

4 Issues per year

CiteScore 2016: 1.04

SCImago Journal Rank (SJR) 2015: 0.401
Source Normalized Impact per Paper (SNIP) 2015: 0.429

See all formats and pricing
More options …

Iatrogenic venous thrombosis secondary to supplemental medicine toxicity

Christopher Ryan Newey / Aarti Sarwal / Deborah Tepper
Published Online: 2013-08-20 | DOI: https://doi.org/10.1515/jcim-2012-0003


Objective: We described a case of cerebral venous sinus thrombosis in a patient taking multiple supplements as part of a naturopathic anti-aging regimen.

Methods: Case report.

Results: The patient presented with a thalamic infarct associated with a thrombus in the vein of Galen. He reported no previous history of endocrinopathy and no known hypercoagulability risk factors. He was treated with therapeutic anticoagulation resulting in improvement. Diagnostic workup revealed hyperthyroidism and gonadotrophic deficiency attributed to significant supplement medicine usage.

Conclusion: This case highlights a potential risk of dietary supplements. Use of these supplements may be a risk factor for idiopathic cerebral venous thrombosis.

Keywords: cerebral venous thrombosis,; hyperthyroidism,; gonadotropin deficiency


  • 1.

    Orwoll ES, Orwoll RL. Hematologic abnormalities in patients with endocrine and metabolic disorders. Hematol Oncol Clin North Am 1:261–79.PubMedGoogle Scholar

  • 2.

    Horstkamp B. Internal jugular vein thrombosis: a late complication of ovarian hyperstimulation syndrome. Hum Reprod 1996;11:1358–9.PubMedCrossrefGoogle Scholar

  • 3.

    Horstkamp B, Lubke M, Kentenich H, Riess H, Buscher U, and Lichtengegger W. “Internal jugular vein thrombosis caused by resistance to activated protein C as a complication of ovarian hyperstimulation after in-vitro fertilization. Hum Reprod 1996;11:280–2.PubMedCrossrefGoogle Scholar

  • 4.

    Squizzato A, Gerdes VE, Ageno W, and Buller HR. The coagulation system in endocrine disorders: a narrative review. Intern Emerg Med 2007;2:76–83.Web of ScienceCrossrefPubMedGoogle Scholar

  • 5.

    Squizzato A, Romualdi E, Buhler HR, and Gerdes VE. Clinical review: thyroid dysfunction and effects on coagulation and fibrinolysis: a systematic review. J Clin Endocrinol Metab 2007;92:2415–20.CrossrefPubMedWeb of ScienceGoogle Scholar

  • 6.

    Jordan S, Murty M, and Pilon K. Products containing bitter orange or synephrine: suspected cardiovascular adverse reactions. CMAJ 2004;171:993–4.Google Scholar

  • 7.

    Bouchard NC, Howland MA, Greller HA, Hoffman RS, and Nelson LS. Ischemic stroke associated with use of an ephedra-free dietary supplement containing synephrine. Mayo Clin Proc 2005;80:541–5.CrossrefPubMedGoogle Scholar

  • 8.

    Marongiu F, Conti M, Mameli G, Murtas ML, Balzano S, Sorano G, et al. Fibrinogen and fibrinolytic activity in hyperthyroidism before and after antithyroid treatment. J Endocrinol Invest 11:723–5.PubMedGoogle Scholar

  • 9.

    Erem C, Ersoz HO, Karti SS, Ukinc K, Hacihasanoglu A, Deger O, et al. Blood coagulation and fibrinolysis in patients with hyperthyroidism. J Endocrinol Invest 25:345–50.PubMedGoogle Scholar

  • 10.

    Rogers JS, 2nd, Shane SR. Factor VIII activity in normal volunteers receiving oral thyroid hormone. J Lab Clin Med 1983;102:444–9.Google Scholar

  • 11.

    Navot D, Margalioth EJ, Laufer N, Birkenfeld A, Relou A, Rosler A, et al. Direct correlation between plasma renin activity and severity of the ovarian hyperstimulation syndrome. Fertil Steril 1987;48:57–61.PubMedGoogle Scholar

  • 12.

    Todorow S, Schricker ST, Siebzehnruebl ER, Neidhardt B, Wildt L, and Lang N. von Willebrand factor: an endothelial marker to monitor in-vitro fertilization patients with ovarian hyperstimulation syndrome. Hum Reprod 1993;8:2039–46.PubMedGoogle Scholar

  • 13.

    Ozsoylu S, Strauss H, and Diamond LK. Effects of corticosteroids on coagulation of the blood. Nature 1962;195:1214–5.Google Scholar

  • 14.

    Isacson S. Effect of prednisolone on the coagulation and fibrinolytic systems. Scand J Haematol 1970;7:212–16.PubMedGoogle Scholar

  • 15.

    Jorgensen K, Sorensen P, and Freund L. Effect of glucocorticosteroids on some coagulation tests. Acta Haematol 68:39–42.PubMedGoogle Scholar

  • 16.

    Brotman DJ, Girod JP, Posch A, Jani JT, Patel JV, Gupta M, et al. Effects of short-term glucocorticoids on hemostatic factors in healthy volunteers. Thromb Res 2006;118:247–52.PubMedCrossrefGoogle Scholar

  • 17.

    van Giezen JJ, Brakkee JG, Dreteler GH, Bouma BN, and Jansen JW. Dexamethasone affects platelet aggregation and fibrinolytic activity in rats at different doses which is reflected by their effect on arterial thrombosis. Blood Coagul Fibrinolysis 1994;5:249–55.CrossrefGoogle Scholar

  • 18.

    Milliez P, Girerd X, Plouin PF, Blacher J, Safar ME, and Mourad JJ. Evidence for an increased rate of cardiovascular events in patients with primary aldosteronism. J Am Coll Cardiol 2005;45:1243–8.PubMedCrossrefGoogle Scholar

  • 19.

    Traber M. Vitamin E and K interactions – a 50-year-old problem. Nutr Rev 2008;66:624–9.Web of ScienceCrossrefGoogle Scholar

  • 20.

    Chesney C, Elam M, Herd JA, Davis KB, Garg R, Hunninghake D, et al. Effect of niacin, warfarin, and antioxidant therapy on coagulation parameters in patients with peripheral arterial disease in the Arterial Disease Multiple Intervention Trial (ADMIT). Am Heart J 2000;140:631–36.Google Scholar

  • 21.

    Finnegan Y, Howarth D, Minihane AM, Kew S, Miller GJ, Calder PC, et al. Plant and marine derived (n–3) polyunsaturated fatty acids do not affect blood coagulation and fibrinolytic factors in moderately hyperlipidemic humans. J Nutr 2003;133:2210–13.Google Scholar

About the article

Received: 2011-05-27

Accepted: 2012-12-07

Published Online: 2013-08-20

Citation Information: Journal of Complementary and Integrative Medicine, ISSN (Online) 1553-3840, ISSN (Print) 2194-6329, DOI: https://doi.org/10.1515/jcim-2012-0003.

Export Citation

©2013 by Walter de Gruyter Berlin / Boston. Copyright Clearance Center

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Natsumi Tanabe, Eiji Hiraoka, Masataka Hoshino, Gautam A. Deshpande, Kana Sawada, Yasuhiro Norisue, Jumpei Tsukuda, and Toshihiko Suzuki
American Journal of Case Reports, 2017, Volume 18, Page 194
Reactions Weekly, 2015, Volume 1564, Number 1, Page 210

Comments (0)

Please log in or register to comment.
Log in