Jump to ContentJump to Main Navigation
Show Summary Details

Journal of Complementary and Integrative Medicine

Editor-in-Chief: Lui, Edmund

Ed. by Ko, Robert / Leung, Kelvin Sze-Yin / Saunders, Paul / Suntres, Zacharias


SCImago Journal Rank (SJR) 2015: 0.401
Source Normalized Impact per Paper (SNIP) 2015: 0.429
Impact per Publication (IPP) 2015: 1.255

49,00 € / $74.00 / £37.00*

Online
ISSN
1553-3840
See all formats and pricing

 


Select Volume and Issue
Loading journal volume and issue information...

Antimalarial potential of China 30 and Chelidonium 30 in combination therapy against lethal rodent malaria parasite: Plasmodium berghei

1Panjab University, Chandigarh, India

Citation Information: Journal of Complementary and Integrative Medicine. Volume 10, Issue 1, Pages 89–96, ISSN (Online) 1553-3840, ISSN (Print) 2194-6329, DOI: 10.1515/jcim-2012-0016, June 2013

Publication History

Received:
2012-09-11
Accepted:
2013-03-08
Published Online:
2013-06-15

Abstract: Homeopathy is a therapeutic method based on the application of similia principle, utilizing ultra-low doses of medicinal substances made from natural products. The present study has been designed to evaluate the efficacy of Cinchona officinalis (Chin.) 30C and Chelidonium majus (Chel.) 30C in combination therapy against lethal murine malaria. Five groups having twelve BALB/c mice each were administered orally with 0.2 ml/mouse/day of different drugs, and their antimalarial potential was evaluated by Peter’s 4-day test. The combination of Chin. 30 and Chel. 30 exhibited complete parasite clearance by the 28th day post-inoculation which was similar to the positive control [artesunate (4 mg/kg)+sulphadoxine-primethamine (1.2 mg/kg)] group. Both the groups exhibited enhanced mean survival time (MST) 28±0 days,whereas, the mice of infected control group survived up to 7.6±0.4 days only. The preventive and curative activities of the combination in comparison to the positive controls [pyrimethamine (1.2 mg/Kg) and chloroquine (20 mg/Kg), respectively] were also evaluated. The combination had a significant preventive activity (p<0.0005), with 89.2% chemosuppression which was higher than the standard drug, pyrimethamine (83.8%). It also showed a moderate curative activity with complete clearance of parasite in 50% of surviving mice, and enhancing the MST of mice up to 26.8±2.8 days. These findings point to the significant antiplasmodial efficacy of the combination of these homeopathic drugs against Plasmodium berghei.

Keywords: homeopathy; Plasmodium berghei; Cinchona; Chelidonium majus

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
Leoni Villano Bonamin, Thayná Neves Cardoso, Aloísio Cunha de Carvalho, and Juliana Gimenez Amaral
Homeopathy, 2015, Volume 104, Number 4, Page 283

Comments (0)

Please log in or register to comment.