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Journal of Complementary and Integrative Medicine

Editor-in-Chief: Lui, Edmund

Ed. by Ko, Robert / Leung, Kelvin Sze-Yin / Saunders, Paul / Suntres, PH. D., Zacharias


CiteScore 2017: 1.41

SCImago Journal Rank (SJR) 2017: 0.472
Source Normalized Impact per Paper (SNIP) 2017: 0.564

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1553-3840
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Antidiabetic and antihypertensive effect of Virgin Argan Oil in model of neonatal streptozotocin-induced diabetic and l-nitroarginine methylester (l-NAME) hypertensive rats

Said Bellahcen
  • Laboratory of Physiology and Ethnopharmacology, URAC 40, Faculty of Sciences, Department of Biology, University Mohamed Ist, Boulevard Mohamed VI, BP:717, 60 000 Oujda, Morocco
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/ Zineb Hakkou
  • Laboratory of Physiology and Ethnopharmacology, URAC 40, Faculty of Sciences, Department of Biology, University Mohamed Ist, Boulevard Mohamed VI, BP:717, 60 000 Oujda, Morocco
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/ Abderrahim Ziyyat
  • Laboratory of Physiology and Ethnopharmacology, URAC 40, Faculty of Sciences, Department of Biology, University Mohamed Ist, Boulevard Mohamed VI, BP:717, 60 000 Oujda, Morocco
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/ Abdelkhaleq Legssyer
  • Laboratory of Physiology and Ethnopharmacology, URAC 40, Faculty of Sciences, Department of Biology, University Mohamed Ist, Boulevard Mohamed VI, BP:717, 60 000 Oujda, Morocco
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/ Hassane Mekhfi
  • Laboratory of Physiology and Ethnopharmacology, URAC 40, Faculty of Sciences, Department of Biology, University Mohamed Ist, Boulevard Mohamed VI, BP:717, 60 000 Oujda, Morocco
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/ Mohammed Aziz
  • Laboratory of Physiology and Ethnopharmacology, URAC 40, Faculty of Sciences, Department of Biology, University Mohamed Ist, Boulevard Mohamed VI, BP:717, 60 000 Oujda, Morocco
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/ Mohamed Bnouham
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  • Laboratory of Physiology and Ethnopharmacology, URAC 40, Faculty of Sciences, Department of Biology, University Mohamed Ist, Boulevard Mohamed VI, BP:717, 60 000 Oujda, Morocco
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Published Online: 2013-07-06 | DOI: https://doi.org/10.1515/jcim-2013-0008

Abstract

Background: The goal of this study was to examine the effect of Virgin Argan Oil (VAO) obtained from the fruit of Argania spinosa in a model of type 2 diabetes and hypertensive rats. Neonatal diabetes was induced by a single i.p. injection of streptozotocin (90 mg/kg) 2 days after birth. To induce NO-deficient hypertension, the adult diabetic animals were treated with l-nitroarginine methylester (l-NAME) (30 mg/kg/day) given orally for 21 days.

Methods: Following treatment with VAO (21 days), the hyperglycemia decreased to 1.3 ± 0.07 g/l compared with 1.92 ± 0.09 g/l (p < 0.01) in the untreated diabetic-hypertensive rats. The simultaneous administration of VAO with l-NAME prevented the increase in blood pressure during the 3 weeks of treatment. Blood pressure remained constant at 131 ± 1 mm Hg after 21 days – vs 157 ± 0.64 mm Hg in untreated animals (p < 0.001).

Results: The treatment with VAO to diabetic-hypertensive rats caused a significant increase of hepatic glycogen levels (13.3 ± 1.8 vs 6.34 ± 0.75 mg/g tissue in untreated diabetic-hypertensive control group; p < 0.01).

Conclusions: In conclusion, the overall findings indicate that VAO possesses antidiabetic and antihypertensive activity in n-stz/l-NAME rats. This effect may be related to its high content of tocopherols, phenolic compounds, and unsaturated fatty acids.

Keywords: Argan oil; diabetes; hyperglycemia; hypertension; l-NAME; streptozotocin

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About the article

Received: 2013-02-25

Accepted: 2013-05-16

Published Online: 2013-07-06


Citation Information: Journal of Complementary and Integrative Medicine, Volume 10, Issue 1, Pages 29–36, ISSN (Online) 1553-3840, ISSN (Print) 2194-6329, DOI: https://doi.org/10.1515/jcim-2013-0008.

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