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Journal of Complementary and Integrative Medicine

Editor-in-Chief: Lui, Edmund

Ed. by Ko, Robert / Leung, Kelvin Sze-Yin / Saunders, Paul / Suntres, PH. D., Zacharias

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CiteScore 2016: 1.04

SCImago Journal Rank (SJR) 2015: 0.401
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1553-3840
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Antiplasmodial potential of homeopathic drugs Chelidonium and nosode against Plasmodium berghei infection

Upma Bagai / Neha S. Walter
Published Online: 2014-07-19 | DOI: https://doi.org/10.1515/jcim-2013-0006

Abstract

Background: Malaria remains a major global health concern in developing regions of the world. Homeopathy, a holistic system of medicine, has a lot to offer in protecting against malaria.

Methods: In the present study, antimalarial efficacy of combination of two homeopathic drugs Chelidonium 30 and nosode 30 has been evaluated in vivo against Plasmodium berghei (P. berghei) infection using Peters 4-day test. Biochemical assays have been performed to assess the levels of hepatic and renal function biomarkers upon drug treatment using diagnostic kits.

Results: The combination of the drugs demonstrated considerable in vivo antimalarial activity with chemosuppression of 91.45% on day 7. The combination also significantly (p<0.0005) enhanced the mean survival time of mice which was calculated to be 22.5±6.31 days, whereas it was 8.55±0.83 days in infected control. The increase in levels of the liver function marker enzymes tested in serum of treated mice were significantly less (p<0.0005) than those observed in infected control on day 10. The serum urea and creatinine used for assessment of renal sufficiency were slightly elevated above normal, but were statistically significant (p<0.0005) as compared to infected control.

Conclusions: The study establishes the effectiveness of the combination against P. berghei in vivo along with the safety of the drugs to the liver and kidney functions of the host.

Keywords: antimalarial; Chelidonium; chemosuppression; nosode

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About the article

Received: 2013-02-11

Accepted: 2014-05-20

Published Online: 2014-07-19

Published in Print: 2014-09-01


Citation Information: Journal of Complementary and Integrative Medicine, ISSN (Online) 1553-3840, ISSN (Print) 2194-6329, DOI: https://doi.org/10.1515/jcim-2013-0006.

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