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Journal of Complementary and Integrative Medicine

Editor-in-Chief: Lui, Edmund

Ed. by Ko, Robert / Leung, Kelvin Sze-Yin / Saunders, Paul / Suntres, PH. D., Zacharias

CiteScore 2017: 1.41

SCImago Journal Rank (SJR) 2017: 0.472
Source Normalized Impact per Paper (SNIP) 2017: 0.564

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Antiplasmodial potential of homeopathic drugs Chelidonium and nosode against Plasmodium berghei infection

Upma Bagai / Neha S. Walter
Published Online: 2014-07-19 | DOI: https://doi.org/10.1515/jcim-2013-0006


Background: Malaria remains a major global health concern in developing regions of the world. Homeopathy, a holistic system of medicine, has a lot to offer in protecting against malaria.

Methods: In the present study, antimalarial efficacy of combination of two homeopathic drugs Chelidonium 30 and nosode 30 has been evaluated in vivo against Plasmodium berghei (P. berghei) infection using Peters 4-day test. Biochemical assays have been performed to assess the levels of hepatic and renal function biomarkers upon drug treatment using diagnostic kits.

Results: The combination of the drugs demonstrated considerable in vivo antimalarial activity with chemosuppression of 91.45% on day 7. The combination also significantly (p<0.0005) enhanced the mean survival time of mice which was calculated to be 22.5±6.31 days, whereas it was 8.55±0.83 days in infected control. The increase in levels of the liver function marker enzymes tested in serum of treated mice were significantly less (p<0.0005) than those observed in infected control on day 10. The serum urea and creatinine used for assessment of renal sufficiency were slightly elevated above normal, but were statistically significant (p<0.0005) as compared to infected control.

Conclusions: The study establishes the effectiveness of the combination against P. berghei in vivo along with the safety of the drugs to the liver and kidney functions of the host.

Keywords: antimalarial; Chelidonium; chemosuppression; nosode


  • 1.

    Bourdy M, Willcox L, Ginsburg H, Rasoanaivo P, Graz B, Deharo E. Ethnopharmacology and malaria: new hypothetical leads or old efficient antimalarials? Int J Parasitol 2008;38:33–41.Web of SciencePubMedGoogle Scholar

  • 2.

    Lira-Salazar G, Marines-Montiel E, Torres-Monzon J, Hernandez-Hernandez F, Salas-Benito JS. Effects of homeopathic medications Eupatorium perfoliatum and Arsenicum album on parasitaemia of Plasmodium berghei infected mice. Homeopathy 2006;95:223–8.CrossrefGoogle Scholar

  • 3.

    Taborska E, Bochorakova H, Dostal J, Paulova H. The greater celandine Chelidonium majus L. – a review of present knowledge. Ceska Slov Farm 1995;44:71–5.Google Scholar

  • 4.

    Partington T, Ruchira DA, Hennel L, Pittendrigh A, Taylor J. Silent and deadly, prophylaxis and treatment of malaria. Homeopath Pract 2006;Spring:14–19.Google Scholar

  • 5.

    Rajan A, Bagai U. Effect of homeopathic medicine Chelidonium against blood stage infection of rodent malaria parasite. In: Bandyopadhyay PK, editor. Proceedings of the 22nd national congress of parasitology, Oct 30th to Nov 1st, 2010, Advances in parasitology: a novel approach towards a disease free world. India: University of Kalyani, West Bengal, 2011:23–31.Google Scholar

  • 6.

    Bagai U, Rajan A, Kaur S. Antimalarial potential of Nosode 30 and 200 against Plasmodium berghei infection in Balb/c mice. J Vector Borne Dis 2012;49:72–7.PubMedGoogle Scholar

  • 7.

    Ernst E. Is homeopathy a clinically valuable approach? Trends Pharmacol Sci 2005;26:547–8.PubMedCrossrefGoogle Scholar

  • 8.

    Garba IH, Gregory U. Serum alkaline phosphatase activity as a potential biomarker for the integrity of the hepatic drainage system in acute falciparum infection. Int J Infect Dis 2005;4:13–16.Google Scholar

  • 9.

    Nayyar B, Rishi P, Shukla G. Plasmodium berghei induced biochemical alterations in pregnant mice. Nepal Med Coll J 2007;9:46–9.PubMedGoogle Scholar

  • 10.

    White NJ, Ho M. The pathophysiology of malaria. Adv Parasitol 1992;31:84–167.Google Scholar

  • 11.

    Adekunle AS, Adekunle OC, Egbewale BE. Serum status of selected biochemical parameters in malaria: an animal model. Biomed Res 2007;18:109–13.Google Scholar

  • 12.

    Ogbadoyi EO, Tsado RD. Renal and hepatic dysfunction in malaria patients in Minna North Central Nigeria. Online J Health Allied Sci 2009;8:8.Google Scholar

  • 13.

    Achliya GS, Wadodkar SG, Dorle AK. Evaluation of hepatoprotective effect of Amalkadi Ghrita against carbon tetrachloride-induced hepatic damage in rats. J Ethnopharmacol 2004;90:229–32.PubMedCrossrefGoogle Scholar

  • 14.

    Ewaraiah MC, Satyanarayana I. Hepatoprotective activity of extracts from stem of Mussaenda erythrophylla Lam. against carbon tetrachloride- induced toxicity in rats. JPRHC 2010;2:23–31.Google Scholar

  • 15.

    Wroblewski F, La Due JS. Serum glutamic oxaloacetic transaminase activity as an index of liver cell injury from cancer. A prelim report. Cancer 1955;8:1155–63.CrossrefGoogle Scholar

  • 16.

    Molander DW, Sheppard E, Payne MA. Serum transaminase in liver disease. J Med Assoc 1957;163:1461–5.CrossrefGoogle Scholar

  • 17.

    Zelman S, Wang CC, Appelhanz I. Transaminases in needle aspiration biopsies. Am J Med Sci 1959;237:323–3.PubMedCrossrefGoogle Scholar

  • 18.

    Smith GL, Shlipak MG, Havranek EP, Foody JM, Masoudi FA, Rathore SS, et al. Serum urea nitrogen, creatinine, and estimators of renal function. Arch Intern Med 2006;166:1134–42.CrossrefPubMedGoogle Scholar

  • 19.

    Kochar DK, Saxena V, Singh N, Kochar SK, Kumar SV, Das A. Plasmodium vivax malaria. Emerg Infect Dis 2005;11:132–4.PubMedCrossrefGoogle Scholar

  • 20.

    Davis TM, Pongponratan E, Supanaranond W, Pukrittaykamee S, Helliwell T, Holloway P, et al. Skeleton muscle involvement in falciparum malaria: biochemical and ultrastructure study. Clin Infect Dis 1999;29:831–5.CrossrefGoogle Scholar

  • 21.

    Narayanan S, Appleton HD. Creatinine: a review. Clin Chem 1980;26:1119–26.PubMedGoogle Scholar

  • 22.

    Mouton R, Holder K. Laboratory tests of renal function. Anaesth Intensive Care Med 2006;7:240–3.CrossrefGoogle Scholar

  • 23.

    Obianime AW, Aprioku JS. Comparative study of artesunate, ACT’s and their combinants on the biochemical parameters of male guinea pigs. Afr J Biotechnol 2009;8:5059–65.Google Scholar

About the article

Received: 2013-02-11

Accepted: 2014-05-20

Published Online: 2014-07-19

Published in Print: 2014-09-01

Citation Information: Journal of Complementary and Integrative Medicine, Volume 11, Issue 3, Pages 195–201, ISSN (Online) 1553-3840, ISSN (Print) 2194-6329, DOI: https://doi.org/10.1515/jcim-2013-0006.

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