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Journal of Complementary and Integrative Medicine

Editor-in-Chief: Lui, Edmund

Ed. by Ko, Robert / Leung, Kelvin Sze-Yin / Saunders, Paul / Suntres, PH. D., Zacharias

CiteScore 2017: 1.41

SCImago Journal Rank (SJR) 2017: 0.472
Source Normalized Impact per Paper (SNIP) 2017: 0.564

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Improvement of restless legs syndrome by nabat: a case series and new hypotheses for research

Ruohollah Seddigh
  • Iran University of Medical Sciences – Mental Health Research Center, Tehran, Islamic Republic of Iran
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Amir-Abbas Keshavarz-Akhlaghi
  • Corresponding author
  • Iran University of Medical Sciences – Mental Health Research Center, Tehran, Islamic Republic of Iran
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2016-02-03 | DOI: https://doi.org/10.1515/jcim-2014-0069


Background: Although many hypotheses have been suggested, the pathophysiology of restless legs syndrome (RLS) has not been fully understood. In this case series, we describe eleven cases with RLS whose symptoms subsided by the use of crystallized sucrose. This kind of sugar, known as nabat, is used in traditional Iranian medicine.

Methods: Case series.

Results: All patients felt relief 30–60 min after taking 100 grams of dissolved nabat.

Conclusions: Sucrose seems to carry a special benefit for patients with RLS, and it provides evidence for growing literature demonstrating the different underlying mechanisms of RLS. Possible causes for this concurrence are also discussed.

Keywords: fructose; glucose; nabat; restless legs syndrome; sleep


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About the article

Received: 2015-03-17

Accepted: 2015-10-09

Published Online: 2016-02-03

Published in Print: 2016-03-01

Citation Information: Journal of Complementary and Integrative Medicine, Volume 13, Issue 1, Pages 91–95, ISSN (Online) 1553-3840, ISSN (Print) 2194-6329, DOI: https://doi.org/10.1515/jcim-2014-0069.

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