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Journal of Complementary and Integrative Medicine

Editor-in-Chief: Lui, Edmund

Ed. by Ko, Robert / Leung, Kelvin Sze-Yin / Saunders, Paul / Suntres, PH. D., Zacharias


CiteScore 2017: 1.41

SCImago Journal Rank (SJR) 2017: 0.472
Source Normalized Impact per Paper (SNIP) 2017: 0.564

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1553-3840
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Improvement of restless legs syndrome by nabat: a case series and new hypotheses for research

Ruohollah Seddigh
  • Iran University of Medical Sciences – Mental Health Research Center, Tehran, Islamic Republic of Iran
  • Other articles by this author:
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/ Amir-Abbas Keshavarz-Akhlaghi
  • Corresponding author
  • Iran University of Medical Sciences – Mental Health Research Center, Tehran, Islamic Republic of Iran
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2016-02-03 | DOI: https://doi.org/10.1515/jcim-2014-0069

Abstract

Background: Although many hypotheses have been suggested, the pathophysiology of restless legs syndrome (RLS) has not been fully understood. In this case series, we describe eleven cases with RLS whose symptoms subsided by the use of crystallized sucrose. This kind of sugar, known as nabat, is used in traditional Iranian medicine.

Methods: Case series.

Results: All patients felt relief 30–60 min after taking 100 grams of dissolved nabat.

Conclusions: Sucrose seems to carry a special benefit for patients with RLS, and it provides evidence for growing literature demonstrating the different underlying mechanisms of RLS. Possible causes for this concurrence are also discussed.

Keywords: fructose; glucose; nabat; restless legs syndrome; sleep

References

  • 1. Reinhold T, Muller-Riemenschneider F, Willich SN, Bruggenjurgen B. Economic and human costs of restless legs syndrome. Pharmacoeconomics 2009;27:267–79.Google Scholar

  • 2. Michaud M, Soucy JP, Chabli A, Lavigne G, Montplaisir J. SPECT imaging of striatal pre- and postsynaptic dopaminergic status in restless legs syndrome with periodic leg movements in sleep. J Neurol 2002;249:164–70.Google Scholar

  • 3. Connor JR, Ponnuru P, Wang XS, Patton SM, Allen RP, Earley CJ. Profile of altered brain iron acquisition in restless legs syndrome. Brain 2011;134:959–68.Web of ScienceGoogle Scholar

  • 4. Sugita Y. Is restless legs syndrome an entirely neurological disorder? Eur J Gen Pract 2008;14:45–6.Google Scholar

  • 5. Walters AS. Opioids and restless legs syndrome. Lancet Neurol 2013;12:1128–9.Web of SciencePubMedGoogle Scholar

  • 6. Oksenberg A. Alleviation of severe restless legs syndrome (RLS) symptoms by cigarette smoking. J Clin Sleep Med 2010;6:489–90.Google Scholar

  • 7. Levin BE. Glucose-regulated dopamine release from substantia nigra neurons. Brain Res 2000;874:158–64.Google Scholar

  • 8. Allen RP, Barker PB, Horska A, Earley CJ. Thalamic glutamate/glutamine in restless legs syndrome: increased and related to disturbed sleep. Neurology 2013;80:2028–34.Google Scholar

  • 9. Allen RP, Picchietti DL, Garcia-Borreguero D, Ondo WG, Walters AS, Winkelman JW, et al. Restless legs syndrome/Willis-Ekbom disease diagnostic criteria: updated International Restless Legs Syndrome Study Group (IRLSSG) consensus criteria – history, rationale, description, and significance. Sleep Med 2014;15:860–73.Google Scholar

  • 10. Walters AS, LeBrocq C, Dhar A, Hening W, Rosen R, Allen RP, et al. Validation of the International Restless Legs Syndrome Study Group rating scale for restless legs syndrome. Sleep Med 2003;4:121–32.Google Scholar

  • 11. Farrahi Moghaddam J, Nakhaee N, Sheibani V, Garrusi B, Amirkafi A. Reliability and validity of the Persian version of the Pittsburgh Sleep Quality Index (PSQI-P). Sleep Breath 2012;16:79–82.Web of ScienceGoogle Scholar

  • 12. Trenkwalder C, Paulus W. Restless legs syndrome: pathophysiology, clinical presentation and management. Nat Rev Neurol 2010;6:337–46.Google Scholar

  • 13. Garcia-Borreguero D, Kohnen R, Silber MH, Winkelman JW, Earley CJ, Hogl B, et al. The long-term treatment of restless legs syndrome/Willis-Ekbom disease: evidence-based guidelines and clinical consensus best practice guidance: a report from the International Restless Legs Syndrome Study Group. Sleep Med 2013;14:675–84.Web of ScienceGoogle Scholar

  • 14. Lipford MC, Silber MH. Long-term use of pramipexole in the management of restless legs syndrome. Sleep Med 2012;13:1280–5.Web of ScienceGoogle Scholar

  • 15. Winkelman JW, Johnston L. Augmentation and tolerance with long-term pramipexole treatment of restless legs syndrome (RLS). Sleep Med 2004;5:9–14.Google Scholar

  • 16. GHolamhoseni por A, Varidi MJ, Elahi M, SHahedi F. Optimization of traditional production process of rock candy. J Sci Technol Agric Nat Resources Water Soil Sci 2009;13:85–93.Google Scholar

  • 17. Institute of Standards and Industrial Research of IranCandy sugar – specifications and test methods, 2nd ed. Available athttp://www.isiri.org/portal/files/std/739.pdf. [In Persian]

  • 18. Perez-Lloret S, Rey MV, Bondon-Guitton E, Rascol O, Montastruc AJ. Drugs associated with restless legs syndrome: a case/noncase study in the French Pharmacovigilance Database. J Clin Psychopharmacol 2012;32:824–7.Google Scholar

  • 19. Howell MJ, Schenck CH. Restless nocturnal eating: a common feature of Willis-Ekbom Syndrome (RLS). J Clin Sleep Med 2012;8:413–9.Google Scholar

  • 20. Innes KE, Selfe TK, Agarwal P. Restless legs syndrome and conditions associated with metabolic dysregulation, sympathoadrenal dysfunction, and cardiovascular disease risk: a systematic review. Sleep Med Rev 2012;16:309–39.Web of ScienceGoogle Scholar

  • 21. Koshimura K, Tanaka J, Murakami Y, Kato Y. Effect of high concentration of glucose on dopamine release from pheochromocytoma-12 cells. Metabolism 2003;52:922–6.Google Scholar

  • 22. Colantuoni C, Rada P, McCarthy J, Patten C, Avena NM, Chadeayne A, et al. Evidence that intermittent, excessive sugar intake causes endogenous opioid dependence. Obes Res 2002;10:478–88.Google Scholar

  • 23. Avena NM, Bocarsly ME, Rada P, Kim A, Hoebel BG. After daily bingeing on a sucrose solution, food deprivation induces anxiety and accumbens dopamine/acetylcholine imbalance. Physiol Behav 2008;94:309–15.Web of ScienceGoogle Scholar

  • 24. Ondo WG. Restless legs syndrome: pathophysiology and treatment. Curr Treat Options Neurol 2014;16:317.Web of ScienceGoogle Scholar

  • 25. Walters AS, Winkelmann J, Trenkwalder C, Fry JM, Kataria V, Wagner M, et al. Long-term follow-up on restless legs syndrome patients treated with opioids. Mov Disord 2001;16:1105–9.Google Scholar

  • 26. Scalise A, Cadore IP, Gigli GL. Motor cortex excitability in restless legs syndrome. Sleep Med 2004;5:393–6.Google Scholar

  • 27. Gunduz A, Adatepe NU, Kiziltan ME, Karadeniz D, Uysal O. Circadian changes in cortical excitability in restless legs syndrome. J Neurol Sci 2012;316:122–5.Google Scholar

  • 28. Rosen AS, Andrew RD. Glucose concentration inversely alters neocortical slice excitability through an osmotic effect. Brain Res 1991;555:58–64.Google Scholar

  • 29. Badawy RA, Vogrin SJ, Lai A, Cook MJ. Cortical excitability changes correlate with fluctuations in glucose levels in patients with epilepsy. Epilepsy Behav 2013;27:455–60.Web of ScienceGoogle Scholar

  • 30. Tramontina AC, Nardin P, Quincozes-Santos A, Tortorelli L, Wartchow KM, Andreazza AC, et al. High-glucose and S100B stimulate glutamate uptake in C6 glioma cells. Neurochem Res 2012;37:1399–408.Google Scholar

  • 31. Earley CJ, Allen RP, Connor JR, Ferrucci L, Troncoso J. The dopaminergic neurons of the A11 system in RLS autopsy brains appear normal. Sleep Med 2009;10:1155–7.Google Scholar

  • 32. Hirata K, Suzuki K. Diagnosis and novel treatment approaches in restless legs syndrome: I. Pathophysiology and diagnosis.Brain Nerve 2013;65:1185–97.Google Scholar

  • 33. Paulus W, Dowling P, Rijsman R, Stiasny-Kolster K, Trenkwalder C, de Weerd A. Pathophysiological concepts of restless legs syndrome. Mov Disord 2007;22:1451–6.Google Scholar

  • 34. Page KA, Chan O, Arora J, Belfort-Deaguiar R, Dzuira J, Roehmholdt B, et al. Effects of fructose vs glucose on regional cerebral blood flow in brain regions involved with appetite and reward pathways. JAMA 2013;309:63–70.Google Scholar

  • 35. Bosco D, Plastino M, Fava A, Ettore M, Bosco F, Ermio CRole of the Oral Glucose Tolerance Test (OGTT) in the idiopathic restless legs syndrome. J Neurol Sci 2009;287:60–3.Web of ScienceGoogle Scholar

About the article

Received: 2015-03-17

Accepted: 2015-10-09

Published Online: 2016-02-03

Published in Print: 2016-03-01


Citation Information: Journal of Complementary and Integrative Medicine, Volume 13, Issue 1, Pages 91–95, ISSN (Online) 1553-3840, ISSN (Print) 2194-6329, DOI: https://doi.org/10.1515/jcim-2014-0069.

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