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Journal of Complementary and Integrative Medicine

Editor-in-Chief: Lui, Edmund

Ed. by Ko, Robert / Leung, Kelvin Sze-Yin / Saunders, Paul / Suntres, PH. D., Zacharias


CiteScore 2017: 1.41

SCImago Journal Rank (SJR) 2017: 0.472
Source Normalized Impact per Paper (SNIP) 2017: 0.564

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1553-3840
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A double-blind, randomized and placebo-controlled trial of Saffron (Crocus sativus L.) in the treatment of anxiety and depression

Mohsen Mazidi
  • Key State Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Chaoyang, Beijing, P.R. China
  • Institute of Genetics and Developmental Biology, International College, University of Chinese Academy of Science (IC-UCAS), West Beichen Road, Chaoyang, P.R. China
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/ Maryam Shemshian
  • Biochemistry of Nutrition Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
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/ Seyed Hadi Mousavi
  • Pharmacological Research Center of Medicinal Plant, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
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/ Abdolreza Norouzy
  • Biochemistry of Nutrition Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
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/ Tayebe Kermani / Toktam Moghiman
  • Biochemistry of Nutrition Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
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/ Akram Sadeghi
  • Department of Anatomy and Cellular Biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
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/ Naghme Mokhber
  • Psychiatry and Behavioral Sciences Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
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/ Majid Ghayour-Mobarhan
  • Corresponding author
  • Biochemistry of Nutrition Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  • Cardiovascular Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
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/ Gordon A. A. Ferns
  • Division of Medical Education, Brighton & Sussex Medical School, University of Brighton, Brighten, UK
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Published Online: 2016-04-21 | DOI: https://doi.org/10.1515/jcim-2015-0043

Abstract

Background: Depression and anxiety are prevalent serious psychiatric disorders. Several drugs are used to treat these conditions but these are often associated with serious side effects. For this reason alternative therapies, including herbal medication such as saffron, have been proposed. We aimed to assess the effects of saffron extract for the treatment of anxiety and depression using a 12-week double-blind, placebo-controlled trial design.

Methods: Sixty adult patients with anxiety and depression were randomized to receive a 50 mg saffron capsule (Crocus sativus L. stigma) or a placebo capsule twice daily for 12 weeks. Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI) questionnaires were used at baseline, 6 and 12 weeks after initiating medication. 54 subjects completed the trial.

Results: Saffron supplements had a significant effect on the BDI and BAI scores of subjects in comparison to placebo at the 12 week time-point (p<0.001).

Conclusions: Saffron appears to have a significant impact in the treatment of anxiety and depression disorder. Side effects were rare.

Keywords: anxiety; Beck Anxiety Inventory (BAI); Beck Depression Inventory (BDI); depression; saffron

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About the article

aMohsen Mazidi and Seyed Hadi Mousavi contributed equally to this work.


Received: 2015-06-20

Accepted: 2016-03-11

Published Online: 2016-04-21

Published in Print: 2016-06-01


Citation Information: Journal of Complementary and Integrative Medicine, Volume 13, Issue 2, Pages 195–199, ISSN (Online) 1553-3840, ISSN (Print) 2194-6329, DOI: https://doi.org/10.1515/jcim-2015-0043.

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