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Journal of Complementary and Integrative Medicine

Editor-in-Chief: Lui, Edmund

Ed. by Ko, Robert / Leung, Kelvin Sze-Yin / Saunders, Paul / Suntres, PH. D., Zacharias

CiteScore 2017: 1.41

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Comparison of honey and phenytoin (PHT) cream effects on intensity of pain and episiotomy wound healing in nulliparous women

Mohadesseh Lavaf
  • Department of Midwifery and Reproductive Health, School of Nursing and Midwifery, Shahid Beheshti University of Medical Science, Tehran, Iran
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/ Masoumeh Simbar
  • Corresponding author
  • Midwifery and Reproductive Health Research Center (MRHRC), Department of Midwifery and Reproductive Health, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Vali-Asr Avenue, Cross of Vali-Asr and Neiaiesh Highway Tehran. Postal code: 1996835119Tehran, Iran (Islamic Republic of)
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/ Faraz Mojab
  • Department of Pharmacognosy, School of Pharmacy and Research Center of Pharmaceutical sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran (Islamic Republic of)
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/ Hamid Alavi Majd
  • Department of Biostatistics, School of Paramedicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran (Islamic Republic of)
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/ Mansoureh Samimi
  • Department of Obstetrics and Gynecology, Faculty of Medicine, University of Medical Sciences, Kashan, Iran (Islamic Republic of)
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  • De Gruyter OnlineGoogle Scholar
Published Online: 2017-10-05 | DOI: https://doi.org/10.1515/jcim-2016-0139



This study investigates and compares the effect of phenytoin and honey cream on intensity of pain and episiotomy wound healing in nulliparous women.


This research was conducted by double-blinded randomized clinical trial method on 120 nulliparous women in three groups of phenytoin, honey and placebo. After delivery and episiotomy, mothers used a knuckle of the prescribed creams on their episiotomy area, every night until 10-night. Evaluation of wound healing using REEDA scale and pain intensity with numerical rating scale of pain took place within the first 24 h and after 7 and 14 days of delivery.


Results showed significant differences between healing scores of the three groups for the seventh day after delivery. Healing score in the honey group was lower than that in placebo group. On the fourteenth day after delivery, the healing scores showed no significant differences between the three groups. Measuring pain intensity did not show any significant difference in the three groups after 7 and 14 days of delivery.


Both honey and phenytoin led to episiotomy wound healing; however, honey caused the wound healing better than the phenytoin. Honey and phenytoin did not reduce episiotomy pain.

Keywords: episiotomy; honey cream; pain intensity; phenytoin cream; wound healing


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About the article

Received: 2016-11-24

Accepted: 2017-07-03

Published Online: 2017-10-05

Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

Research funding: None declared.

Employment or leadership: None declared.

Honorarium: None declared.

Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.

Citation Information: Journal of Complementary and Integrative Medicine, Volume 15, Issue 1, 20160139, ISSN (Online) 1553-3840, DOI: https://doi.org/10.1515/jcim-2016-0139.

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