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Journal of Complementary and Integrative Medicine

Editor-in-Chief: Lui, Edmund

Ed. by Ko, Robert / Leung, Kelvin Sze-Yin / Saunders, Paul / Suntres, PH. D., Zacharias

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The beneficial effects of pumpkin extract on atherogenic lipid, insulin resistance and oxidative stress status in high-fat diet-induced obese rats

Atefe Ghahremanloo / Reza Hajipour / Mina Hemmati
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  • Birjand CardioVascular Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran
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/ Maryam Moossavi / Zabihullah Mohaqiq
Published Online: 2017-10-24 | DOI: https://doi.org/10.1515/jcim-2017-0051



Prevention and treatment of obesity is a way to reduce cardiovascular disease, diabetes and depression. Pumpkin as a favorable plant has different properties notably antioxidant, lipid-lowering and anti-diabetic potential. The aim of this study was to assess the anti-obesity effects of pumpkin in diet-induced obese rats.


Thirty adult male Wistar rats were randomly divided into five groups (n=6) of healthy control, dietary fatty control rats, and three experimental dietary fatty rats that received hydro-alcoholic extract of pumpkin once daily at doses 100 and 200 and 400 mg/kg, respectively. At the end of 6 weeks, lipid profile, atherogenicity, liver enzymes, and oxidative stress status were measured.


Pumpkin in a dose-dependent manner dramatically decreased triglycerides and low-density lipoprotein, and liver enzymes while high-density lipoprotein was markedly increased in treated groups. Pumpkin also increased glutathione level in comparison with obese control group.


Pumpkin ameliorated oxidative stress and dyslipidemia in obese rats, leading to decrease cardiovascular disease risk in obesity.

Keywords: insulin resistance; obesity; pumpkin extract


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About the article

Received: 2017-07-06

Accepted: 2017-07-27

Published Online: 2017-10-24

This investigation was supported by Grant No. 77.93 from the office of Vice Chancellor research, Birjand University of Medical Sciences.

Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

Employment or leadership: None declared.

Honorarium: None declared.

Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.

Citation Information: Journal of Complementary and Integrative Medicine, Volume 15, Issue 2, 20170051, ISSN (Online) 1553-3840, DOI: https://doi.org/10.1515/jcim-2017-0051.

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