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Journal of Complementary and Integrative Medicine

Editor-in-Chief: Lui, Edmund

Ed. by Ko, Robert / Leung, Kelvin Sze-Yin / Saunders, Paul / Suntres, PH. D., Zacharias

CiteScore 2017: 1.41

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Ameliorative potential of acupressure on gestational diabetes mellitus: A randomized controlled trial

Fayiz F. El-Shamy
  • Department of physical therapy for women’s health, Faculty of physical therapy, Kafrelsheikh university, Kafrelsheikh, Egypt
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Sanad S. El-Kholy / Mahmoud Labib
  • Department of physical therapy for internal medicine and geriatrics, Faculty of physical therapy, Kafrelsheikh university, Kafrelsheikh, Egypt
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Ahmed M. Kabel
  • Corresponding author
  • Pharmacology department, Faculty of medicine, Tanta university, Tanta, Egypt
  • Department of clinical pharmacy, College of pharmacy, Taif university, Taif, Saudi Arabia
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2018-06-21 | DOI: https://doi.org/10.1515/jcim-2018-0011


Background and aim

Gestational diabetes mellitus (GDM) poses a threat to the mother and child. The aim of this study was to examine the effect of acupressure on the glycemic control and insulin requirement of GDM females.

Materials and methods

Thirty GDM female patients were randomized to either the study group (SG; n=15), which was treated with acupressure and the standard antenatal care, or the control group (CG; n=15), which was treated with the standard antenatal care. Fasting and 2-h post-prandial blood glucose levels, requirement for insulin and insulin resistance were measured at 24 and 36 weeks’ gestation (WG). Also, neonatal outcomes were registered at delivery.


The pre intervention showed no statistically significant differences between SG and CG for baseline characteristics of participants (p>0.05). Within group analyses, after 12 weeks intervention had shown that 75 g oral glucose tolerance test (OGTT), insulin resistance, number of required insulin and measure of utilized insulin were significantly reduced (p<0.05), with significant increase in body mass index (BMI) (p<0.05) in both groups. All outcome measures were not significantly changed (p>0.05) between both groups at 24 and 36 WG. No significant differences (p>0.05) in pregnancy and neonatal outcomes between both groups at labor.


Acupressure may help to reduce gestational diabetes or insulin treatment for overweight female patients with GDM.

Keywords: acupressure; diabetes mellitus; insulin therapy; pregnancy


  • [1]

    Scholl TO, Sowers M, Chen X, Lenders C. Maternal glucose concentration influences fetal growth, gestation, and pregnancy complications. Am J Epidemiol. 2001;154:514–20.CrossrefPubMedGoogle Scholar

  • [2]

    Mirghani Dirar A, Doupis J. Gestational diabetes from A to Z. World J Diabetes. 2017;8:489–511.Web of ScienceCrossrefGoogle Scholar

  • [3]

    Jovanovic L, Pettitt DJ. Gestational diabetes mellitus. JAMA. 2001;286:2516–8.CrossrefPubMedGoogle Scholar

  • [4]

    Tutino G, Tam W, Yang X, Chan J, Lao T, Ma C. Diabetes and pregnancy: perspectives from Asia. BMC Pregnancy Childbirth. 2014;31:302–18.Google Scholar

  • [5]

    Jimenez-Moleon JJ, Bueno-Cavanillas A, Luna-del-Castillo Jde D, Garcia-Martin M, Lardelli-Claret P, Galvez-Vargas R. Impact of different levels of carbohydrate intolerance on neonatal outcomes classically associated with gestational diabetes mellitus. Eur J Obstet Gynecol Reprod Biol. 2002;102:36–41.PubMedCrossrefGoogle Scholar

  • [6]

    Liu J, Wang SZ, Wang QL, Du JG, Wang BB. Gestational diabetes mellitus is associated with changes in the concentration and bioactivity of placental exosomes in the maternal circulation across gestation. Eur Rev Med Pharmacol Sci. 2018;22:2036–43.PubMedGoogle Scholar

  • [7]

    Bellamy L, Casas JP, Hingorani AD, Williams D. Type 2 diabetes mellitus after gestational diabetes: a systematic review and meta-analysis. Lancet. 2009;373:1773–9.Web of SciencePubMedCrossrefGoogle Scholar

  • [8]

    Landon MB, Spong CY, Thom E, Carpenter MW, Ramin SM, Casey B, et al. A multicenter, randomized trial of treatment for mild gestational diabetes. N Engl J Med. 2009;361:1339–48.Web of SciencePubMedCrossrefGoogle Scholar

  • [9]

    Bastani F. Effect of acupressure on maternal anxiety in women with gestational diabetes mellitus: a randomized clinical trial. Clin Nurs Res. 2016;25:325–41.PubMedWeb of ScienceCrossrefGoogle Scholar

  • [10]

    Meyer-Hamme G, Friedemann T, Greten HJ, Plaetke R, Gerloff C, Schroeder S. ACUDIN - acupuncture and laser acupuncture for treatment of diabetic peripheral neuropathy: a randomized, placebo-controlled, partially double-blinded trial. BMC Neurol. 2018;18:40.CrossrefPubMedWeb of ScienceGoogle Scholar

  • [11]

    Beijing college of traditional medicine, Shanghai college of traditional medicine, Nanjing college of traditional medicine and The acupuncture institute of the academy of college of traditional medicine, editors. Essentials of Chinese acupuncture. Beijing: Foreign languages press, 1980.Google Scholar

  • [12]

    Gabrielle NB, Mitchell BF, Edmond AR, Nanette BO. Resistance exercise decreases the need for insulin in overweight women with gestational diabetes mellitus. Am J Obstet Gynecol. 2004;190:188–93.PubMedCrossrefGoogle Scholar

  • [13]

    Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28:412–9.PubMedCrossrefGoogle Scholar

  • [14]

    Alberti KG, Zimmet PZ. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med. 1998;15:539–53.CrossrefPubMedGoogle Scholar

  • [15]

    National Council on Nutrition and Physical Activity in Norway. Extract from the Norwegian national report on physical activity and health. Scand J Med Sci Sports. 2001;11:255–7.PubMedGoogle Scholar

  • [16]

    Zierath JR Invited review: exercise training-induced changes in insulin signaling in skeletal muscle. J Appl Physiol. 2002;93:773–81.PubMedCrossrefGoogle Scholar

  • [17]

    Jovanovic-Peterson L, Durak EP, Peterson CM. Randomized trial of diet versus diet plus cardiovascular conditioning on glucose levels in gestational diabetes. Am J Obstet Gynecol. 1989;161:415–9.PubMedCrossrefGoogle Scholar

  • [18]

    Avery MD, Walker AJ. Acute effect of exercise on blood glucose and insulin levels in women with gestational diabetes. J Matern Fetal Med. 2001;10:52–8.PubMedCrossrefGoogle Scholar

  • [19]

    Artal R. Exercise: the alternative therapeutic intervention for gestational diabetes. Clin Obstet Gynecol. 2003;46:479–87.CrossrefPubMedGoogle Scholar

  • [20]

    Helmrich SP, Ragland DR, Paffenbarger RS. Prevention of noninsulin- dependent diabetes mellitus with physical activity. Med Sci Sports Exerc. 1994;26:824–30.PubMedGoogle Scholar

  • [21]

    Kuhl C. Etiology and pathogenesis of gestational diabetes. Diabetes Care. 1998;21:B19–26.PubMedGoogle Scholar

  • [22]

    Langer O, Levy J, Brustman L, Anyaegbunam A, Merkatz R, Divon M. Glycemic control in gestational diabetes mellitus: how tight is tight enough? Small for gestational age versus large for gestational age. Am J Obstet Gynecol. 1989;161:646–53.PubMedCrossrefGoogle Scholar

  • [23]

    El-Mekawy HS, El Deeb AM, Ghareib HO. Effect of laser acupuncture combined with a diet-exercise intervention on metabolic syndrome in post-menopausal women. J Advanced Res. 2015;6:757–63.CrossrefWeb of ScienceGoogle Scholar

  • [24]

    Field T, Diego M, Hernandez-Reif M, Figueiredo B, Deeds O, Ascencio A, et al. Comorbid depression and anxiety effects on pregnancy and neonatal outcome. Infant Behav Dev. 2010;33:23–9.PubMedCrossrefWeb of ScienceGoogle Scholar

  • [25]

    Hui H. A review of treatment of diabetes by acupuncture during the past forty years. J Tradit Chin Med. 1995;15:145–54.PubMedGoogle Scholar

  • [26]

    DeFronzo RA. Pharmacologic therapy for type 2 diabetes mellitus. Ann Intern Med. 1999;131:281–303.PubMedCrossrefGoogle Scholar

  • [27]

    Farideh B. Effect of acupressure on maternal anxiety in women with gestational diabetes mellitus: a randomized clinical trial. Clin Nurs Res. 2016;25:325–41.PubMedWeb of ScienceCrossrefGoogle Scholar

  • [28]

    Stafne N, Kjell A, Pal R, Torbjørn M, Sven M, Mørkved S. Regular exercise during pregnancy to prevent gestational diabetes a randomized controlled trial. Obstetrics Gynecol. 2012;119:29–36.CrossrefWeb of ScienceGoogle Scholar

About the article

Received: 2018-01-26

Accepted: 2018-05-07

Published Online: 2018-06-21

Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

Research funding: None declared.

Employment or leadership: None declared.

Honorarium: None declared.

Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.

Citation Information: Journal of Complementary and Integrative Medicine, Volume 16, Issue 1, 20180011, ISSN (Online) 1553-3840, DOI: https://doi.org/10.1515/jcim-2018-0011.

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