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Journal of Complementary and Integrative Medicine

Editor-in-Chief: Lui, Edmund

Ed. by Ko, Robert / Leung, Kelvin Sze-Yin / Saunders, Paul / Suntres, PH. D., Zacharias


CiteScore 2017: 1.41

SCImago Journal Rank (SJR) 2017: 0.472
Source Normalized Impact per Paper (SNIP) 2017: 0.564

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1553-3840
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Fenugreek dermal patch, a new natural topical antinociceptive medication for relieving the postherniotomy pain, a double-blind placebo controlled trial

Mehdi Ansari
  • Pharmaceutics Research Center, Institute of Neuropharmacology, Department of Pharmaceutics, Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran
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/ Parvane Sadeghi
  • Pharmaceutics Research Center, Institute of Neuropharmacology, Department of Pharmaceutics, Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran
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/ Hamid Mahdavi
  • Department of Novel Drug Delivery Systems, Iran Polymer and Petrochemical Institut, Tehran, Iran
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/ Mohsen Fattahi-Dolatabadi / Neda Mohamadi
  • Herbal and Traditional Medicines Research Center, Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran
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/ Amir Asadi
  • Herbal and Traditional Medicines Research Center, Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran
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/ Fariba Sharififar
  • Corresponding author
  • Herbal and Traditional Medicines Research Center, Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran
  • Email
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Published Online: 2019-02-05 | DOI: https://doi.org/10.1515/jcim-2018-0082

Abstract

Background

Fenugreek seeds have shown antinociceptive effect in animal studies. This double-blind placebo controlled trial was designed to study the effect of fenugreek transdermal patch 10% (FDP) for management of inguinal hernia (IH) post-operative pain.

Methods

Standardized extract of fenugreek seeds was used for FDP formulation. Ninety patients treated with 10% FDP, diclofenac dermal patch 1% (DP) and placebo twice daily after IH surgery. The pain intensity score was evaluated using a visual analogue score (VAS) up to 48 h after operation. Morphine consumption and diclofenac suppository demand were evaluated too.

Results

The pain score was significantly reduced in FDP group in comparison with the placebo group. This effect was also significantly different from DP up to 6 h after surgery (p<0.05). Morphine consumption and diclofenc suppository demand were significantly decreased in FDP group (p<0.05).

Conclusion

In all, results of the present study indicated that FDP decreases pain score and demand for morphine in post-surgery patients in comparison to diclofenac patch, and this preparation could be a suit option as a natural antinociceptive agent for pain management.

Keywords: antinociceptive; double-blind placebo controlled trial; fenugreek; inguinal hernia; transdermal patch

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About the article

Received: 2018-05-17

Accepted: 2018-09-12

Published Online: 2019-02-05


Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

Research funding: This trial was funded through a clinical study grant by Vice Chancellor of Research of Kerman University of Medical Sciences, Kerman, Iran (grant No. 93/356).

Employment or leadership: None declared.

Honorarium: None declared.

Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.


Citation Information: Journal of Complementary and Integrative Medicine, 20180082, ISSN (Online) 1553-3840, DOI: https://doi.org/10.1515/jcim-2018-0082.

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