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Journal of Complementary and Integrative Medicine

Editor-in-Chief: Lui, Edmund

Ed. by Ko, Robert / Leung, Kelvin Sze-Yin / Saunders, Paul / Suntres, PH. D., Zacharias

CiteScore 2017: 1.41

SCImago Journal Rank (SJR) 2017: 0.472
Source Normalized Impact per Paper (SNIP) 2017: 0.564

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Dietary antioxidant for disease prevention corroborated by the Nrf2 pathway

Amany M. Hegazy / Eman M. El-Sayed / Khadiga S. Ibrahim
  • Corresponding author
  • Department of Environmental and Occupational Medicine, National Research Centre, Dokki, Giza, Egypt
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Amal S. Abdel-Azeem
Published Online: 2019-02-05 | DOI: https://doi.org/10.1515/jcim-2018-0161


Dietary antioxidants are widely distributed in various types of our food. They are strongly associated with reduced risk of many chronic diseases such as atherosclerosis, cancer, and Alzheimer’s diseases. They include vitamins such as vitamins A, E, C, and carotenoids. Also, some minerals like; zinc, manganese, copper, iron, and selenium are essential for the activity of antioxidant enzymes. Furthermore, dietary polyphenols and flavonoids are considered as potent antioxidant compounds. Vegetables, fruits, and edible herbs are the richest sources of such antioxidants. Antioxidants reduce oxidative stress, either directly by reducing reactive species or indirectly by enhancing the body antioxidant defense mechanisms in different ways. These may include upregulating gene expression of some antioxidant enzymes via a nuclear factor erythroid 2 related factor2 pathway. Administration of a mixture of antioxidants is beneficial since they act synergistically in various phases. The aims of this review are to summarize the different antioxidants from dietary sources and their role in the prevention of different diseases.

Keywords: dietary antioxidants; diseases; herbs; Nrf2; oxidative stress


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About the article

The authors declare that this manuscript has not been submitted elsewhere or not under consideration of publication.

Received: 2018-09-19

Accepted: 2018-10-28

Published Online: 2019-02-05

Author contributions: AH and AA put the primary idea of the article and participated in collecting data. EM and KS modified the idea of the article, collecting data, writing, reviewing, and editing. All authors read and approved the final manuscript.

Novelty and contribution of this work: The link between the antioxidants and diseases is still poorly understood. therefore we tried to clarify the role of such antioxidants in various diseases. Also, we focused on their function in the induction of the nuclear factor erythroid 2 related factor2 by screening various review.

Research funding: None declared.

Employment or leadership: None declared.

Honorarium: None declared.

Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.

Citation Information: Journal of Complementary and Integrative Medicine, 20180161, ISSN (Online) 1553-3840, DOI: https://doi.org/10.1515/jcim-2018-0161.

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