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The Journal of Haemophilia Practice

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2055-3390
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Myocardial infarction in severe haemophilia

Jenique Bailly
  • Associate Lecturer, Department of Molecular Medicine and Haematology, University of the Witwatersrand, Johannesburg, South Africa
  • Other articles by this author:
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/ Professor Johnny Mahlangu
  • Corresponding author
  • Head of Clinical Haematology, Haemophilia Comprehensive Care Centre, Charlotte Maxeke Johannesburg Academic Hospital, Johannesburg, South Africa
  • Professor of Haematology, Department of Molecular Medicine and Haematology, University of the Witwatersrand and NHLS, Johannesburg, South Africa
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Published Online: 2018-04-14 | DOI: https://doi.org/10.17225/jhp00108

Abstract

With improved replacement therapy, people with haemophilia (PWH) live longer, with the consequent emergence of age-related chronic diseases not previously seen in haemophilia. The prevalence of cardiovascular disease and associated complications in older PWH appears to be on the rise. Management of myocardial infarction in a person living with severe haemophilia presents a particular challenge, as treatment options often include antiplatelet therapy, anti-coagulation and invasive procedures. Current guidelines for managing acute myocardial infarction are not specifically designed for people with bleeding diatheses such as haemophilia. We present a patient with severe haemophilia A on extended half-life factor VIII prophylaxis who developed an acute ST-elevation myocardial infarction (STEMI), discuss his clinical management and highlight lessons learned.

Keywords: Coagulation disorders; Myocardial infarction; Severe haemophilia

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About the article

Published Online: 2018-04-14


Citation Information: The Journal of Haemophilia Practice, Volume 5, Issue 1, Pages 8–11, ISSN (Online) 2055-3390, DOI: https://doi.org/10.17225/jhp00108.

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© 2018. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License. BY-NC-ND 4.0

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