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Journal of Integrative Bioinformatics

Editor-in-Chief: Schreiber, Falk / Hofestädt, Ralf

Managing Editor: Sommer, Björn

Ed. by Baumbach, Jan / Chen, Ming / Orlov, Yuriy / Allmer, Jens

Editorial Board: Giorgetti, Alejandro / Harrison, Andrew / Kochetov, Aleksey / Krüger, Jens / Ma, Qi / Matsuno, Hiroshi / Mitra, Chanchal K. / Pauling, Josch K. / Rawlings, Chris / Fdez-Riverola, Florentino / Romano, Paolo / Röttger, Richard / Shoshi, Alban / Soares, Siomar de Castro / Taubert, Jan / Tauch, Andreas / Yousef, Malik / Weise, Stephan / Hassani-Pak, Keywan


CiteScore 2017: 0.77

SCImago Journal Rank (SJR) 2017: 0.336

Open Access
Online
ISSN
1613-4516
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Volume 4, Issue 3

Issues

Stochastic effects in a compartmental model for mitotic checkpoint regulation

Bashar Ibrahim
  • Jena Centre for Bioinformatics & Institute of Computer Science, Friedrich-Schiller-University Jena, D-07737 Jena, http://www.minet.uni-jena.de, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Peter Dittrich
  • Jena Centre for Bioinformatics & Institute of Computer Science, Friedrich-Schiller-University Jena, D-07737, Jena, http://www.minet.uni-jena.de, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Stephan Diekmann
  • Leibniz Institute for Age Research – FLI, Beutenbergstraße 11, D-07745 Jena, http://www.fli-leibniz.de, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Eberhard Schmitt
  • Corresponding author
  • Leibniz Institute for Age Research – FLI, Beutenbergstraße 11, D-07745 Jena, http://www.fli-leibniz.de, Germany
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2016-10-18 | DOI: https://doi.org/10.1515/jib-2007-66

Summary

The proper segregation of sister chromatids at onset of anaphase is surveyed by the mitotic spindle assembly checkpoint. The concentration dynamics of the complexes APC:Cdc20 and MCC:APC determine exit from metaphase to anaphase. We have developed a model based on 14 proteins and complexes to describe concentration dynamics by ordinary differential equations in three compartments coupled by diffusion. One kinetochore in each compartment determines the attachment status to the spindle pole. Here, we focus on the role of noise in the segregation surveillance process. The deterministic differential equations are enriched by a stochastic term adding white noise of different amplitudes. Obviously, for the known physiological parameter ranges, noise does not disturb the checkpoint function. On the other hand, there is a connection between diffusion and noise, that could become important when considering a larger number of chromosomes.

About the article

Published Online: 2016-10-18

Published in Print: 2007-12-01


Citation Information: Journal of Integrative Bioinformatics, Volume 4, Issue 3, Pages 77–88, ISSN (Online) 1613-4516, DOI: https://doi.org/10.1515/jib-2007-66.

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© 2007 The Author(s). Published by Journal of Integrative Bioinformatics.. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License. BY-NC-ND 4.0

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[1]
Bashar Ibrahim
Bulletin of Mathematical Biology, 2017, Volume 79, Number 5, Page 1183
[3]
Bashar Ibrahim
Computational and Structural Biotechnology Journal, 2015, Volume 13, Page 320
[4]
Richard Henze, Jan Huwald, Nelly Mostajo, Peter Dittrich, and Bashar Ibrahim
Biosystems, 2015, Volume 127, Page 47
[5]
Dennis Görlich, Gabi Escuela, Gerd Gruenert, Peter Dittrich, and Bashar Ibrahim
Biosemiotics, 2014, Volume 7, Number 2, Page 223
[6]
Bashar Ibrahim, Eberhard Schmitt, Peter Dittrich, and Stephan Diekmann
Biosystems, 2009, Volume 95, Number 1, Page 35
[7]
Bashar Ibrahim, Stephan Diekmann, Eberhard Schmitt, Peter Dittrich, and Kevin Hardwick
PLoS ONE, 2008, Volume 3, Number 2, Page e1555
[8]
Bashar Ibrahim, Peter Dittrich, Stephan Diekmann, and Eberhard Schmitt
Biophysical Chemistry, 2008, Volume 134, Number 1-2, Page 93
[9]
Richard Henze, Chunyan Mu, Mate Puljiz, Nishanthan Kamaleson, Jan Huwald, John Haslegrave, Pietro Speroni di Fenizio, David Parker, Christopher Good, Jonathan E. Rowe, Bashar Ibrahim, and Peter Dittrich
Scientific Reports, 2019, Volume 9, Number 1
[10]
Bashar Ibrahim and Richard Henze
International Journal of Molecular Sciences, 2014, Volume 15, Number 12, Page 19074

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