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Journal of Integrative Bioinformatics

Editor-in-Chief: Schreiber, Falk / Hofestädt, Ralf

Managing Editor: Sommer, Björn

Ed. by Baumbach, Jan / Chen, Ming / Orlov, Yuriy / Allmer, Jens

Editorial Board: Giorgetti, Alejandro / Harrison, Andrew / Kochetov, Aleksey / Krüger, Jens / Ma, Qi / Matsuno, Hiroshi / Mitra, Chanchal K. / Pauling, Josch K. / Rawlings, Chris / Fdez-Riverola, Florentino / Romano, Paolo / Röttger, Richard / Shoshi, Alban / Soares, Siomar de Castro / Taubert, Jan / Tauch, Andreas / Yousef, Malik / Weise, Stephan / Hassani-Pak, Keywan


CiteScore 2017: 0.77

SCImago Journal Rank (SJR) 2017: 0.336

Open Access
Online
ISSN
1613-4516
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Volume 4, Issue 3

Issues

IMS2 – An integrated medical software system for early lung cancer detection using ion mobility spectrometry data of human breath

Jan Baumbach
  • Corresponding author
  • Computational Methods for Emerging Technologies, Genome Informatics, Technische Fakultät, Bielefeld University, 33594, Bielefeld, Germany
  • International NRW Graduate School in Bioinformatics and Genome Research, Bielefeld University, Germany
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Alexander Bunkowski
  • Computational Methods for Emerging Technologies, Genome Informatics, Technische Fakultät, Bielefeld University, 33594, Bielefeld, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Sita Lange
  • Computational Methods for Emerging Technologies, Genome Informatics, Technische Fakultät, Bielefeld University, 33594 Bielefeld, Germany
  • Bioinformatics Resource Facility, Bielefeld University, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Timm Oberwahrenbrock
  • Computational Methods for Emerging Technologies, Genome Informatics, Technische Fakultät, Bielefeld University, 33594 Bielefeld, Germany
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  • De Gruyter OnlineGoogle Scholar
/ Nils Kleinbölting
  • Computational Methods for Emerging Technologies, Genome Informatics, Technische Fakultät, Bielefeld University, 33594 Bielefeld, Germany
  • Bioinformatics Resource Facility, Bielefeld University, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Sven Rahmann
  • Computational Methods for Emerging Technologies, Genome Informatics, Technische Fakultät, Bielefeld University, 33594 Bielefeld, Germany
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  • De Gruyter OnlineGoogle Scholar
/ Jörg Ingo Baumbach
  • Department of Metabolomics, ISAS – Institute for Analytical Sciences, Bunsen-Kirchhoff-Str. 11, 44139, Dortmund, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2016-10-18 | DOI: https://doi.org/10.1515/jib-2007-75

Abstract

IMS2 is an Integrated Medical Software system for the analysis of Ion Mobility Spectrometry (IMS) data. It assists medical staff with the following IMS data processing steps: acquisition, visualization, classification, and annotation. IMS2 provides data analysis and interpretation features on the one hand, and also helps to improve the classification by increasing the number of the pre-classified datasets on the other hand. It is designed to facilitate early detection of lung cancer, one of the most common cancer types with one million deaths each year around the world.

After reviewing the IMS technology, we first describe the software architecture of IMS2 and then the integrated classification module, including necessary pre-processing steps and different classification methods. The Lung Hospital Hemer (Germany) provided IMS data of 35 patients suffering from lung cancer and 72 samples of healthy persons. IMS2 correctly classifies 99% of the samples, evaluated using 10-fold cross-validation.

About the article

Published Online: 2016-10-18

Published in Print: 2007-12-01


Citation Information: Journal of Integrative Bioinformatics, Volume 4, Issue 3, Pages 186–197, ISSN (Online) 1613-4516, DOI: https://doi.org/10.1515/jib-2007-75.

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© 2007 The Author(s). Published by Journal of Integrative Bioinformatics.. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License. BY-NC-ND 4.0

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[2]
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[10]
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[12]
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[13]
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