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Journal of Integrative Bioinformatics

Editor-in-Chief: Schreiber, Falk / Hofestädt, Ralf

Managing Editor: Sommer, Björn

Ed. by Baumbach, Jan / Chen, Ming / Orlov, Yuriy / Allmer, Jens

Editorial Board: Giorgetti, Alejandro / Harrison, Andrew / Kochetov, Aleksey / Krüger, Jens / Ma, Qi / Matsuno, Hiroshi / Mitra, Chanchal K. / Pauling, Josch K. / Rawlings, Chris / Fdez-Riverola, Florentino / Romano, Paolo / Röttger, Richard / Shoshi, Alban / Soares, Siomar de Castro / Taubert, Jan / Tauch, Andreas / Yousef, Malik / Weise, Stephan / Hassani-Pak, Keywan

CiteScore 2017: 0.77

SCImago Journal Rank (SJR) 2017: 0.336

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Volume 4, Issue 3


Functional and Transcriptional Coherency of Modules in the Human Protein Interaction Network

Matthias E. Futschik / Gautam Chaurasia
  • Institute for Theoretical Biology, Charité, Humboldt-University, Berlin, Germany
  • Max Delbrück Center for Molecular Medicine, Berlin, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Anna Tschaut / Jenny Russ / M. Madan Babu
  • MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, United Kingdom of Great Britain and Northern Ireland
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Hanspeter Herzel
Published Online: 2016-10-18 | DOI: https://doi.org/10.1515/jib-2007-76


Modularity is a major design principle in interaction networks. Various studies have shown that protein interaction networks in prokaryotes and eukaryotes display a modular structure. A majority of the studies have been performed for the yeast interaction network, for which data have become abundant. The systematic examination of the human protein interaction network, however, is still in an early phase. To assess whether the human interaction network similarly displays a modular structure, we assembled a large protein network consisting of over 30,000 interactions. More than 670 modules were subsequently identified based on the detection of cliques. Inspection showed that these modules included numerous known protein complexes. The extracted modules were scrutinized for their coherency with respect to function, localization and expression, thereby allowing us to distinguish between stable and dynamic modules. Finally, the examination of the overlap between modules identified key proteins linking distinct molecular processes.

About the article

Published Online: 2016-10-18

Published in Print: 2007-12-01

Citation Information: Journal of Integrative Bioinformatics, Volume 4, Issue 3, Pages 198–207, ISSN (Online) 1613-4516, DOI: https://doi.org/10.1515/jib-2007-76.

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© 2007 The Author(s). Published by Journal of Integrative Bioinformatics.. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License. BY-NC-ND 4.0

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