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Journal of Integrative Bioinformatics

Editor-in-Chief: Schreiber, Falk / Hofestädt, Ralf

Managing Editor: Sommer, Björn

Ed. by Baumbach, Jan / Chen, Ming / Orlov, Yuriy / Allmer, Jens

Editorial Board: Giorgetti, Alejandro / Harrison, Andrew / Kochetov, Aleksey / Krüger, Jens / Ma, Qi / Matsuno, Hiroshi / Mitra, Chanchal K. / Pauling, Josch K. / Rawlings, Chris / Fdez-Riverola, Florentino / Romano, Paolo / Röttger, Richard / Shoshi, Alban / Soares, Siomar de Castro / Taubert, Jan / Tauch, Andreas / Yousef, Malik / Weise, Stephan / Hassani-Pak, Keywan


CiteScore 2017: 0.77

SCImago Journal Rank (SJR) 2017: 0.336

Open Access
Online
ISSN
1613-4516
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Volume 4, Issue 3

Issues

Reactome: An integrated expert model of human molecular processes and access toolkit

Bernard de Bono
  • Corresponding author
  • European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, United Kingdom of Great Britain and Northern Ireland
  • Email
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/ Imre Vastrik
  • European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, United Kingdom of Great Britain and Northern Ireland
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/ Peter D’Eustachio
  • Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor NY 11724, United States of America
  • NYU School of Medicine, 550 First Avenue, New York NY 10016, United States of America
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/ Esther Schmidt
  • European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, United Kingdom of Great Britain and Northern Ireland
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/ Gopal Gopinath
  • Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor NY 11724, United States of America
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/ David Croft
  • European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, United Kingdom of Great Britain and Northern Ireland
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/ Marc Gillespie
  • Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor NY 11724, United States of America
  • College of Pharmacy and Allied Health Professions, St. John’s University, 8000 Utopia Parkway, Queens, NY, 11439, United States of America
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/ Bijay Jassal
  • European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, United Kingdom of Great Britain and Northern Ireland
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/ Suzanna Lewis
  • Lawrence Berkeley National Laboratory, 1 Cyclotron Road 64R0121, Berkeley, CA, 94720, United States of America
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/ Lisa Matthews
  • Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor NY 11724, United States of America
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/ Guanming Wu
  • Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor NY 11724, United States of America
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/ Ewan Birney
  • European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, United Kingdom of Great Britain and Northern Ireland
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/ Lincoln Stein
  • Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor NY 11724, United States of America
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Published Online: 2016-10-18 | DOI: https://doi.org/10.1515/jib-2007-84

Summary

The behaviour of pervasive molecular processes in human biology can be studied through the large-scale modeling of the molecular events that define them. Constructing detailed models of such extent and scope is a considerable undertaking well beyond the reach and capability of individual efforts, due to the range of expertise required. Reactome (http://www.reactome.org) is an open-access project that collaborates with field experts to integrate their pathway knowledge into a single quality-checked human model. This resource dataset is systematically cross-referenced to major molecular and literature databases, and is accessible to the community in a number of well-established formats. Various tools have been developed to facilitate querying and interaction with this content. The salient features of the annotation strategy are discussed here, and examples of pathway and genomic data integration using flexible interfacing methods from the associated toolkit are also presented.

About the article

Published Online: 2016-10-18

Published in Print: 2007-12-01


Citation Information: Journal of Integrative Bioinformatics, Volume 4, Issue 3, Pages 286–296, ISSN (Online) 1613-4516, DOI: https://doi.org/10.1515/jib-2007-84.

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© 2007 The Author(s). Published by Journal of Integrative Bioinformatics.. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License. BY-NC-ND 4.0

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