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Journal of Integrative Bioinformatics

Editor-in-Chief: Schreiber, Falk / Hofestädt, Ralf

Managing Editor: Sommer, Björn

Ed. by Baumbach, Jan / Chen, Ming / Orlov, Yuriy / Allmer, Jens

Editorial Board: Giorgetti, Alejandro / Harrison, Andrew / Kochetov, Aleksey / Krüger, Jens / Ma, Qi / Matsuno, Hiroshi / Mitra, Chanchal K. / Pauling, Josch K. / Rawlings, Chris / Fdez-Riverola, Florentino / Romano, Paolo / Röttger, Richard / Shoshi, Alban / Soares, Siomar de Castro / Taubert, Jan / Tauch, Andreas / Yousef, Malik / Weise, Stephan / Hassani-Pak, Keywan


CiteScore 2018: 0.90

SCImago Journal Rank (SJR) 2018: 0.315

Open Access
Online
ISSN
1613-4516
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Volume 5, Issue 2

Issues

Integrative Visual Analysis of the Effects of Alternative Splicing on Protein Domain Interaction Networks

Dorothea Emig
  • Department of Computational Biology and Applied Algorithmics, Max Planck Institute for Informatics, Campus E1.4, 66123 Saarbrücken, Germany
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/ Melissa S. Cline
  • Department of Molecular Cell and Developmental Biology, University of California, Santa Cruz, CA 95064, United States of America
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/ Karsten Klein
  • Department of Computer Science, Dortmund University of Technology, Otto-Hahn-Str. 14, 44227 Dortmund, Germany
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/ Anne Kunert
  • Department of Computer Science, Dortmund University of Technology, Otto-Hahn-Str. 14, 44227 Dortmund, Germany
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/ Petra Mutzel
  • Department of Computer Science, Dortmund University of Technology, Otto-Hahn-Str. 14, 44227 Dortmund, Germany
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/ Thomas Lengauer
  • Department of Computational Biology and Applied Algorithmics, Max Planck Institute for Informatics, Campus E1.4, 66123 Saarbrücken, Germany
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/ Mario Albrecht
  • Corresponding author
  • Department of Computational Biology and Applied Algorithmics, Max Planck Institute for Informatics, Campus E1.4, 66123 Saarbrücken, Germany
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Published Online: 2016-10-18 | DOI: https://doi.org/10.1515/jib-2008-101

Summary

Proteins and their interactions are essential for the functioning of all organisms and for understanding biological processes. Alternative splicing is an important molecular mechanism for increasing the protein diversity in eukaryotic cells. Splicing events that alter the protein structure and the domain composition can be responsible for the regulation of protein interactions and the functional diversity of different tissues. Discovering the occurrence of splicing events and studying protein isoforms have become feasible using Affymetrix Exon Arrays. Therefore, we have developed the versatile Cytoscape plugin DomainGraph that allows for the visual analysis of protein domain interaction networks and their integration with exon expression data. Protein domains affected by alternative splicing are highlighted and splicing patterns can be compared.

About the article

Published Online: 2016-10-18

Published in Print: 2008-06-01


Citation Information: Journal of Integrative Bioinformatics, Volume 5, Issue 2, Pages 173–187, ISSN (Online) 1613-4516, DOI: https://doi.org/10.1515/jib-2008-101.

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© 2008 The Author(s). Published by Journal of Integrative Bioinformatics.. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License. BY-NC-ND 4.0

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[1]
Falk Schreiber, Tim Dwyer, Kim Marriott, and Michael Wybrow
BMC Bioinformatics, 2009, Volume 10, Number 1

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