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Journal of Integrative Bioinformatics

Editor-in-Chief: Schreiber, Falk / Hofestädt, Ralf

Managing Editor: Sommer, Björn / Kormeier, Benjamin

Ed. by Baumbach, Jan / Chen, Ming / Orlov, Yuriy / Allmer, Jens

Editorial Board: Giorgetti, Alejandro / Harrison, Andrew / Kochetov, Aleksey / Krüger, Jens / Ma, Qi / Matsuno, Hiroshi / Mitra, Chanchal K. / Pauling, Josch K. / Rawlings, Chris / Fdez-Riverola, Florentino / Romano, Paolo / Röttger, Richard / Shoshi, Alban / Soares, Siomar de Castro / Taubert, Jan / Tauch, Andreas / Yousef, Malik / Weise, Stephan

4 Issues per year

Open Access
Online
ISSN
1613-4516
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Volume 13, Issue 5

Issues

miRquant 2.0: an Expanded Tool for Accurate Annotation and Quantification of MicroRNAs and their isomiRs from Small RNA-Sequencing Data

Matthew Kanke / Jeanette Baran-Gale / Jonathan Villanueva
  • Department of Genetics, Chapel Hill, United States of America
  • Post-baccalaurate Research Education Program, Chapel Hill, United States of America
  • Other articles by this author:
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/ Praveen Sethupathy
  • Corresponding author
  • Department of Genetics, Chapel Hill, United States of America
  • Lineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 United States of America
  • Email
  • Other articles by this author:
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Published Online: 2017-04-20 | DOI: https://doi.org/10.1515/jib-2016-307

Summary

Small non-coding RNAs, in particular microRNAs, are critical for normal physiology and are candidate biomarkers, regulators, and therapeutic targets for a wide variety of diseases. There is an ever-growing interest in the comprehensive and accurate annotation of microRNAs across diverse cell types, conditions, species, and disease states. Highthroughput sequencing technology has emerged as the method of choice for profiling microRNAs. Specialized bioinformatic strategies are required to mine as much meaningful information as possible from the sequencing data to provide a comprehensive view of the microRNA landscape. Here we present miRquant 2.0, an expanded bioinformatics tool for accurate annotation and quantification of microRNAs and their isoforms (termed isomiRs) from small RNA-sequencing data. We anticipate that miRquant 2.0 will be useful for researchers interested not only in quantifying known microRNAs but also mining the rich well of additional information embedded in small RNA-sequencing data.

About the article

Published Online: 2017-04-20

Published in Print: 2016-12-01


Citation Information: Journal of Integrative Bioinformatics, Volume 13, Issue 5, Pages 47–56, ISSN (Online) 1613-4516, DOI: https://doi.org/10.1515/jib-2016-307.

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© 2016 The Author(s). Published by Journal of Integrative Bioinformatics.. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License. BY-NC-ND 4.0

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