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Journal of Medical Biochemistry

The Journal of Society of Medical Biochemists of Serbia

4 Issues per year


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1452-8266
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Volume 27, Issue 4 (Oct 2008)

Issues

Cystatin C, Renal Function and Cardiovascular Risk

Carola Wagner
  • Dade Behring Marburg GmbH, A Siemens Company, 35001 Marburg, Germany
Published Online: 2008-08-27 | DOI: https://doi.org/10.2478/v10011-008-0021-4

Cystatin C, Renal Function and Cardiovascular Risk

Cystatin C is a novel serum marker of the glomerular filtration rate (GFR), a critical measure of normal kidney function. Unlike serum creatinine, cystatin C concentrations are independent of gender, age and muscle mass. As cystatin C shown no tubular secretion, it is a much earlier indicator of decreased GFR and allows the detection of mild reductions in GFR, which are not detected by creatinine. Cystatin C has been shown to be associated with future cardiovascular disease and deaths in a dose-dependent relationship that possibly reflects a very early stage of chronic ranal dysfunction. In addition, >sub-clinically< elevated cystatin C concentrations in individuals without chronic kidney disease indicated by creatinine are an independent predictor of progression to chronic kidney disease, heart failure and all-cause mortality.

Cistatin C je novi serumski marker glomerularne filtracije (GFR), od kritičnog značaja za procenu normalne bubrežne funkcije. Za razliku od serumskog kreatinina, koncentracije serumskog cistatina C ne zavise od pola, starosti i mišićne mase. Cistatin C ne podleže tubulrnoj sekreciji, te je mnogo raniji indikator smanjenja GFR što omogućava otkrivanje i neznatnog smanjenja GFR, koje nije moguće otkriti pomoću kreatinina. Cistatin C je udružen sa budućim kardiovaskularnim oboljenjem što ukazuje i na rane stupnjeve hronične renalne disfunkcije. To znači da su «sub-klinička» povećanja koncentracija cistatina C u osoba bez hroničnog oboljenja bubrega indikovana kreatininom nezavisan prediktor progresije hroničnog bubrežnog oboljenja, srčanog oštećenja i smrtnosti.

Keywords: cystatin C; GFR; chronic kidney disease; cardiovascular risk

Keywords: cistin C; GFR; hronično bubrežno oboljenje; kardiovaskularni rizik

  • Tanaka A, Suemaru K, Araki H. A new approach for evaluating renal function and its practical application. J Pharmacol Sci 2007; 105: 1-5. [Web of Science]

  • Jernberg T, Lindahl B, James S et al. Cystatin C - A novel predictor of outcome in suspected or confirmed non-ST-elevation acute coronary syndromes. Circulation 2004; 110: 2342-8.

  • Koenig W, Twardella D, Brenner H et al. Plasma concentrations of cystatin C in patients with coronary heart disease and risk for secondary cardiovascular events: More than simply a marker of glomerular filtration rate. Clin Chem 2005; 51: 321-7.

  • Shlipak MG, Sarnak MJ, Katz R et al. Cystatin C and the risk of death and cardiovascular events among elderly persons. N Engl J Med 2005; 352: 2049-60.

  • Levey AS, Atkins R, Coresh J et al. Chronic kidney disease as a global public health problem: Approaches and initiatives - a position statement from Kidney Disease Improving Global Outcomes. Kidney Int 2007; 72: 247-59. [Web of Science]

  • Levey AS, Eckhardt KU, Tsukamoto Y et al. Definition and classification of chronic kidney disease: A position statement from Kidney Disease: Improving Global Outcomes (KDIGO). Kidney Int 2005; 67: 2089-100. [Web of Science]

  • Herget-Rosenthal S, Bökenkam A, Hofmann W:. How to estimate GFR - serum creatinine, serum cystatin C or equations? Clin Biochem 2007; 40: 153-61. [Web of Science]

  • Roos JF, Doust J, Tett SE et al. Diagnostic accuracy of cystatin C compared to serum creatinine for the estimation of renal dysfunction in adults and children - A meta-analysis. Clin Biochem 2007; 40: 383-91. [Web of Science]

  • Filler G, Priem F, Lepage N et al. ß-Trace protein, cystatin C, ß2-microglobulin, and creatinine compared for detecting impaired glomerular filtration rates in children. Clin Chem 2002; 48: 729-36.

  • Fliser D, Ritz E. Serum cystatin C concentration as a marker of renal dysfunction in the elderly. Am J Kidney Dis 2001; 37: 79-83.

  • Perkins BA, Nelson RG, Ostrander BEP et al. Detection of renal function decline in patients with diabetes and normal or elevated GFR by serial measurement of serum cystatin C concentration: Results of a 4-year follow-up study. J Am Soc Nephrol 2005; 16: 1404-12.

  • Hoek FJ, Kemperman FAW, Krediet RT. A comparison between cystatin C, plasma creatinine and the Cockcroft and Gault formula for the estimation of glomerular filtration rate. Nephrol Dial Transplant 2003; 18: 2024-31.

  • Larsson A, Malm J, Grubb A et al. Calculation of glomerular filtration rate expressed in mL/min from plasma cystatin C values in mg/L. Scand J Clin Lab Invest 2004; 64: 25-30.

  • Beauvieux MC, Le Moigne F, Lasseur C et al. New predictive equations improve monitoring of kidney function in patients with diabetes. Diabetes Care 2007; 30: 1988-94. [Web of Science]

  • Stevens LA, Coresh J, Schmid CH et al. Estimating GFR using serum cystatin C alone and in combination with serum creatinine: A pooled analysis Of 3,418 individuals with CKD. Am J Kidney Dis 2008; 51: 395-406. [Web of Science]

  • Herget-Rosenthal S, Marggraf G, Hüsing J et al. Early detection of acute renal failure by serum cystatin C. Kidney Int 2004; 66: 1115-22.

  • Shlipak MG, Katz R, Sarnak MJ et al. Cystatin C and prognosis for cardiovascular and kidney outcomes in elderly persons without chronic kidney disease. Ann Intern Med 2006; 145: 237-46.

  • Sarnak MJ, Katz R, Stehman-Breen CO et al. Cystatin C concentration as a risk factor for heart failure in older adults. Ann Intern Med 2005; 142: 497-505.

  • Mijušković Z, Maksić DJ, Hrvačević R et al. Urinary Cystatin C as a marker of tubular disfunction. Journal of Medical Biochemistry 2007; 26: 98-102.

  • Sarnak MJ, Katz R, Fried LF et al. Cystatin C and aging success. Arch Intern Med 2008; 168: 147-53. [Web of Science]

  • Hillege HL, Verhave JC, Bakker SJL et al. Cystatin C is superior to serum creatinine in prediction of mortality in the general population; data obtained from the PRE-VEND study. ASN Congress 2003; abstract SA-FC150.

  • Kalansooriya A, Holbrook I, Jennings P et al. Serum cystatin C, enzymuria, tubular proteinuria and early renal insult in type 2 diabetes. Br J Biomed Sci 2007; 64: 121-3.

About the article


Published Online: 2008-08-27

Published in Print: 2008-10-01


Citation Information: Journal of Medical Biochemistry, ISSN (Online) 1452-8266, ISSN (Print) 1452-8258, DOI: https://doi.org/10.2478/v10011-008-0021-4. Export Citation

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