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Journal of Medical Biochemistry

The Journal of Society of Medical Biochemists of Serbia

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Volume 29, Issue 1 (Jan 2010)


The Change of Ghrelin Levels in Intestinal Parasitic Infections

Ahmet Erensoy / Suleyman Aydin
  • Department of Biochemistry and Clinical Biochemistry, School of Medicine, Firat University, Elazig, Turkey
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Neslihan Kelestimur / Sevda Kirbag / Salih Kuk
Published Online: 2010-01-06 | DOI: https://doi.org/10.2478/v10011-010-0004-0

The Change of Ghrelin Levels in Intestinal Parasitic Infections

The aim of this work was to examine the relationship between active (acylated ghrelin) and inactive (desacylated ghrelin) ghrelin in the serum and other serum parameters in intestinal parasitic infections and healthy controls. Conventional microscopic methods (saline and iodine solutions, trichrome stain) were used to identify intestinal parasites in stool samples of 29 subjects attending Firat University Hospital. Serum parameters were assessed in a single measurement of serum from 29 parasite subjects, and in 18 healthy controls. Serum acylated ghrelin and desacylated ghrelin levels were measured using a commercial radioimmunoassay (RIA) kit. Paraoxonase and arylesterase were measured by using a spectrophotometer at 405 nm and 270 nm, respectively. Serum concentrations of acylated ghrelin and desacylated ghrelin were more markedly decreased in helminth bearing patients than the control group. Glucose, cholesterol and triglyceride levels were higher in intestinal parasitic infections than in controls. Furthermore, there were no correlations between ghrelin levels and BMI. These results indicate that low ghrelin and PON1/AE level may be important for appetite monitoring in intestinal parasitic infections.

Promene Nivoa Grelina kod Crevnih Parazitskih Infekcija

Cilj studije bio je da se ispita odnos između aktivnog (aciliranog) i neaktivnog (deaciliranog) grelina u serumu i drugih serumskih parametara kod crevnih parazitskih infekcija i zdravih kontrola. Uobičajene mikroskopske metode (slani rastvor i rastvor joda, trihromatski otisak) korišćene su za identifikaciju crevnih parazita u uzorcima stolice 29 pacijenata Univerzitetske bolnice Firat. Serumski parametri određeni su u jednokratnom merenju seruma 29 pacijenata s parazitima i 18 zdravih kontrolnih subjekata. Nivoi aciliranog grelina i deaciliranog grelina u serumu izmereni su metodom radioimunoeseja. Paraoksonaza i arilesteraza su merene spektrofotometrijski na 405 nm i 270 nm. Koncentracije aciliranog i deaciliranog grelina u serumu bile su upadljivo niže kod pacijenata sa parazitima nego u kontrolnoj grupi. Nivoi glukoze, holesterola i triglicerida bili su viši kod crevnih parazitskih infekcija nego kod kontrola. Štaviše, nije bilo korelacija između nivoa grelina i indeksa telesne mase. Rezultati ukazuju na to da bi niski nivoi grelina i PON1/AE mogli biti važni za praćenje apetita kod crevnih parazitskih infekcija.

Keywords: serum; active/inactive ghrelin; paraoxonase; arylesterase; parasite

Keywords: serum; aktivni/neaktivni grelin; paraoksonaza; arilesteraza; paraziti

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About the article

Published Online: 2010-01-06

Published in Print: 2010-01-01

Citation Information: Journal of Medical Biochemistry, ISSN (Online) 1452-8266, ISSN (Print) 1452-8258, DOI: https://doi.org/10.2478/v10011-010-0004-0.

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