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Roth, Christian

Journal of Pediatric Endocrinology and Metabolism

Editor-in-Chief: Kiess, Wieland

Ed. by Bereket, Abdullah / Cohen, Pinhas / Darendeliler, Feyza / Dattani, Mehul / Gustafsson, Jan / Luo, Feihong / Mericq, Veronica / Toppari, Jorma

Editorial Board Member: Battelino, Tadej / Buyukgebiz, Atilla / Cassorla, Fernando / Chrousos, George P. / Cutfield, Wayne / Fideleff, Hugo L. / Hershkovitz, Eli / Hiort, Olaf / LaFranchi, Stephen H. / Lanes M. D., Roberto / Mohn, Angelika / Root, Allen W. / Rosenfeld, Ron G. / Werther, George / Zadik, Zvi

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2191-0251
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In This Section
Volume 23, Issue 11 (Jan 2010)

Issues

Clinical Presentation and Autoimmune Characteristics of Very Young Children at the Onset of Type 1 Diabetes Mellitus

Bizzarri Carla
  • Corresponding author
  • Unit of Endocrinology and Diabetes, Bambino Gesù Children's Hospital, University of Rome “Tor Vergata”, Piazza S. Onofrio, Rome, Italy
/ Benevento Danila
  • Unit of Endocrinology and Diabetes, Bambino Gesù Children's Hospital, University of Rome “Tor Vergata”, Piazza S. Onofrio, Rome, Italy
/ Ciampalini Paolo
  • Unit of Endocrinology and Diabetes, Bambino Gesù Children's Hospital, University of Rome “Tor Vergata”, Piazza S. Onofrio, Rome, Italy
/ Patera Ippolita Patrizia
  • Unit of Endocrinology and Diabetes, Bambino Gesù Children's Hospital, University of Rome “Tor Vergata”, Piazza S. Onofrio, Rome, Italy
/ Schiaffini Riccardo
  • Unit of Endocrinology and Diabetes, Bambino Gesù Children's Hospital, University of Rome “Tor Vergata”, Piazza S. Onofrio, Rome, Italy
/ Migliaccio Antonella
  • Unit of Endocrinology and Diabetes, Bambino Gesù Children's Hospital, University of Rome “Tor Vergata”, Piazza S. Onofrio, Rome, Italy
/ Ravà Lucilla
  • Epidemiology Unit, Bambino Gesù Children's Hospital, University of Rome “Tor Vergata”, Piazza S. Onofrio, Rome, Italy
/ Cappa Marco
  • Unit of Endocrinology and Diabetes, Bambino Gesù Children's Hospital, University of Rome “Tor Vergata”, Piazza S. Onofrio, Rome, Italy
Published Online: 2010-12-22 | DOI: https://doi.org/10.1515/jpem.2010.180

ABSTRACT

The aim of our study was to identify factors that are related to a more aggressive β-cell destruction in children at presentation of type 1 diabetes mellitus (T1D).

We analyzed age, HbA1c, pH, bicarbonate, IAA, IA2, GADA, C peptide of 290 consecutive patients with T1D at onset. Seventy-three (25.2%) were younger than 4 years; 217 (74.8%) were aged 4-18 years. Younger patients had lower C peptide, pH and bicarbonate than older ones. Age at T1D onset was negatively related to IAA titers (r: -0.3404, p < 0.001), positively related to IA2 titers (r: 0.1249, p: 0.03) and to C peptide (r: 0.42, p: < 0.001). Multivariable linear regression showed that C peptide was negatively related to HbA1c and positively related to age, pH at admission and IAA titers.

T1D in very young children is characterized by a more extensive β-cell destruction, and younger age at onset is related to a more severe decompensation.

KEY WORDS: type 1 diabetes; children; beta cell; ketoacidosis; C peptide

About the article

Corresponding author: Dr. Carla Bizzarri,


Published Online: 2010-12-22

Published in Print: 2010-11-01


Citation Information: Journal of Pediatric Endocrinology and Metabolism, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: https://doi.org/10.1515/jpem.2010.180.

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