Jump to ContentJump to Main Navigation
Show Summary Details
In This Section

Roth, Christian

Journal of Pediatric Endocrinology and Metabolism

Editor-in-Chief: Kiess, Wieland

Ed. by Bereket, Abdullah / Cohen, Pinhas / Darendeliler, Feyza / Dattani, Mehul / Gustafsson, Jan / Luo, Feihong / Mericq, Veronica / Toppari, Jorma

Editorial Board Member: Battelino, Tadej / Buyukgebiz, Atilla / Cassorla, Fernando / Chrousos, George P. / Cutfield, Wayne / Fideleff, Hugo L. / Hershkovitz, Eli / Hiort, Olaf / LaFranchi, Stephen H. / Lanes M. D., Roberto / Mohn, Angelika / Root, Allen W. / Rosenfeld, Ron G. / Werther, George / Zadik, Zvi

12 Issues per year


IMPACT FACTOR 2016: 1.233

CiteScore 2016: 1.09

SCImago Journal Rank (SJR) 2015: 0.493
Source Normalized Impact per Paper (SNIP) 2015: 0.600

Online
ISSN
2191-0251
See all formats and pricing
In This Section
Volume 23, Issue 12 (Jan 2010)

Issues

Does Fat Fuel the Fire: Independent and Interactive Effects of Genetic, Physiological, and Environmental Factors on Variations in Fat Deposition and Distribution across Populations

Lynae J. Hanks
  • Corresponding author
  • Department of Nutrition Sciences and Clinical Nutrition Research Center, University of Alabama at Birmingham, Birmingham, AL, USA
/ Krista Casazza
  • Department of Nutrition Sciences and Clinical Nutrition Research Center, University of Alabama at Birmingham, Birmingham, AL, USA
/ Jessica A. Alvarez
  • Department of Nutrition Sciences and Clinical Nutrition Research Center, University of Alabama at Birmingham, Birmingham, AL, USA
/ Jose R. Fernandez
  • Department of Nutrition Sciences and Clinical Nutrition Research Center, University of Alabama at Birmingham, Birmingham, AL, USA
  • Section on Statistical Genetics, Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA
Published Online: 2011-03-02 | DOI: https://doi.org/10.1515/jpem.2010.197

ABSTRACT

Markers of inflammation (MOI) have been reported to influence bone health in adults, with reports of inverse associations. Adipose has also been linked to bone. In children, the interrelationships are unclear. The objective of this study was to evaluate the relationship between MOI (i.e. CRP, TNFR2, IL-6) and bone mineral content (BMC) and determine the contribution of fat deposition/distribution in children. Forty-nine children (59% male) 7-12 y participated. Body composition was evaluated by DXA, and MOI and insulin sensitivity (SI) were obtained during an IVGTT. Multiple linear regression was used for analyses. TNFR2 was inversely associated with BMC. In boys, TNFR2 was inversely associated with BMC, and in girls IL-6 was inversely associated with BMC, and total and percent fat influenced the relationships. Our results suggest a potential inhibitory role of inflammation on bone as well as a negative impact of adiposity. Future investigations are warranted to further investigate these relationships.

About the article

Corresponding author: Lynae Hanks, MS, RD,


Published Online: 2011-03-02

Published in Print: 2010-12-01



Citation Information: Journal of Pediatric Endocrinology and Metabolism, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: https://doi.org/10.1515/jpem.2010.197. Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
Krista Casazza, Lynae J Hanks, and David A Fields
Bonekey Reports, 2014, Volume 3, Page 577

Comments (0)

Please log in or register to comment.
Log in