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Journal of Pediatric Endocrinology and Metabolism

Editor-in-Chief: Kiess, Wieland

Ed. by Bereket, Abdullah / Cohen, Pinhas / Darendeliler, Feyza / Dattani, Mehul / Gustafsson, Jan / Luo, Feihong / Mericq, Veronica / Roth, Christian / Toppari, Jorma

Editorial Board Member: Battelino, Tadej / Buyukgebiz, Atilla / Cassorla, Fernando / Chrousos, George P. / Cutfield, Wayne / Fideleff, Hugo L. / Hershkovitz, Eli / Hiort, Olaf / LaFranchi, Stephen H. / Lanes M. D., Roberto / Mohn, Angelika / Root, Allen W. / Rosenfeld, Ron G. / Werther, George / Zadik, Zvi

12 Issues per year


IMPACT FACTOR 2016: 1.233

CiteScore 2016: 1.09

SCImago Journal Rank (SJR) 2016: 0.527
Source Normalized Impact per Paper (SNIP) 2016: 0.602

Online
ISSN
2191-0251
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Volume 23, Issue 4 (Jan 2010)

Issues

Primary Aldosteronism and its Impact on the Generation of Arterial Hypertension, Endothelial Injury and Oxidative Stress

Alejandro Martinez-Aguayo
  • Endocrinology Unit, Department of Paediatrics, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile
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/ Cristian A. Carvajal
  • Department of Endocrinology, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile
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/ Carmen Campino
  • Department of Endocrinology, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile
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/ Marlene Aglony
  • Nephrology Unit; Department of Paediatrics, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile
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/ Lillian Bolte
  • Nephrology Unit; Department of Paediatrics, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile
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/ Hernán Garcia
  • Endocrinology Unit, Department of Paediatrics, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile
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/ Carlos E. Fardella
  • Corresponding author
  • Department of Endocrinology, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile
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Published Online: 2010-09-17 | DOI: https://doi.org/10.1515/jpem.2010.052

ABSTRACT

Aldosterone plays an important role in blood pressure homeostasis, the regulation of circulating volume, and the maintenance of the sodium-potassium balance by binding to the mineralocorticoid receptor (MR). Primary aldosteronism (PA) states are associated with an increased cardiovascular risk, mediated not only by hypertension but also by the action of aldosterone in the modulation of vasodilation / vasoconstriction and oxidative stress. In this review, we discuss some of the cardiovascular actions of aldosterone and the most frequent causes of PA.

KEY WORDS: primary aldosteronism; endothelial injury; oxidative stress and arterial hypertension

About the article

Corresponding author: Prof. Carlos Fardella, MD,


Published Online: 2010-09-17

Published in Print: 2010-04-01


Citation Information: Journal of Pediatric Endocrinology and Metabolism, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: https://doi.org/10.1515/jpem.2010.052.

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[1]
Eric R. Barros and Cristian A. Carvajal
Frontiers in Endocrinology, 2017, Volume 8
[2]
Simonetta Friso, Cristian A. Carvajal, Carlos E. Fardella, and Oliviero Olivieri
Translational Research, 2015, Volume 165, Number 1, Page 154
[3]
Carolina Loureiro, Carmen Campino, Alejandro Martinez-Aguayo, Ivan Godoy, Marlene Aglony, Rodrigo Bancalari, Hernan Garcia, Cristian A. Carvajal, and Carlos Fardella
Clinical Endocrinology, 2013, Volume 78, Number 3, Page 352

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