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Journal of Pediatric Endocrinology and Metabolism

Editor-in-Chief: Kiess, Wieland

Ed. by Bereket, Abdullah / Cohen, Pinhas / Darendeliler, Feyza / Dattani, Mehul / Gustafsson, Jan / Luo, Feihong / Mericq, Veronica / Roth, Christian / Toppari, Jorma

Editorial Board Member: Battelino, Tadej / Buyukgebiz, Atilla / Cassorla, Fernando / Chrousos, George P. / Cutfield, Wayne / Fideleff, Hugo L. / Hershkovitz, Eli / Hiort, Olaf / LaFranchi, Stephen H. / Lanes M. D., Roberto / Mohn, Angelika / Root, Allen W. / Rosenfeld, Ron G. / Werther, George / Zadik, Zvi

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Primary Aldosteronism and its Impact on the Generation of Arterial Hypertension, Endothelial Injury and Oxidative Stress

Alejandro Martinez-Aguayo1 / Cristian A. Carvajal2 / Carmen Campino2 / Marlene Aglony3 / Lillian Bolte3 / Hernán Garcia1 / Carlos E. Fardella2

1Endocrinology Unit, Department of Paediatrics, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile

2Department of Endocrinology, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile

3Nephrology Unit; Department of Paediatrics, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile

Corresponding author: Prof. Carlos Fardella, MD,

Citation Information: Journal of Pediatric Endocrinology and Metabolism. Volume 23, Issue 4, Pages 323–330, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: 10.1515/jpem.2010.052, September 2010

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Aldosterone plays an important role in blood pressure homeostasis, the regulation of circulating volume, and the maintenance of the sodium-potassium balance by binding to the mineralocorticoid receptor (MR). Primary aldosteronism (PA) states are associated with an increased cardiovascular risk, mediated not only by hypertension but also by the action of aldosterone in the modulation of vasodilation / vasoconstriction and oxidative stress. In this review, we discuss some of the cardiovascular actions of aldosterone and the most frequent causes of PA.

KEY WORDS: primary aldosteronism; endothelial injury; oxidative stress and arterial hypertension

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