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Journal of Pediatric Endocrinology and Metabolism

Editor-in-Chief: Kiess, Wieland

Ed. by Bereket, Abdullah / Darendeliler, Feyza / Dattani, Mehul / Gustafsson, Jan / Luo, Fei Hong / Mericq, Veronica / Ogata, Tsutomu / Toppari, Jorma

12 Issues per year


IMPACT FACTOR 2017: 1.086

CiteScore 2017: 1.07

SCImago Journal Rank (SJR) 2017: 0.465
Source Normalized Impact per Paper (SNIP) 2017: 0.580

Online
ISSN
2191-0251
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Volume 23, Issue 8

Issues

Confirmation of Neonatal Screening: Reference Intervals and Evaluation of Methodological Changes in TSH Measurement

Gabriel Fideleff / Martha G. Suárez / Patricia G. V. Sobrado / María L. Celadilla / Mario Mardyks / Carmen C. Rodriguez / Ana Jelen / Hugo R. Boquete / Hugo L. Fideleff
Published Online: 2010-09-17 | DOI: https://doi.org/10.1515/jpem.2010.125

ABSTRACT

Neonatal reference values for serum thyrotropin are scarce and comprise only small numbers of patients. During 2006, changes were made in IMMULITE kits for TSH measurement. To validate methodological changes, 80 serum samples from patients were evaluated and to establish reference intervals, 334 neonates and infants were analyzed (divided into 4 groups). Group 1 (G1) (48-72 h of life) (n=153), group 2A (G2A) (7-10 days of life) (n =65), group 2B (G2B) (11- 14 days of life) (n= 35), group 3 (G3) (28-40 days of life) (n =81). Current kits overestimate TSH results by 26 to 37%; TSH (mIU/L) reference intervals (percentile 2.5 – 97.5) were G1 (1.1-12.7), G2A (1.8-9.8), G2B (1.1-7.1) (p<0.03 vs G2A), G3 (1.2-6.9). We suggest that during the second week of life, reference values should be divided into an early stage and a late stage, at least, for there to be an adequate interpretation of borderline measurements in newborn thyroid screening.

KEY WORDS: TSH; thyrotropin; neonatal screening; congenital hypothyroidism; thyroid hormones

About the article

Corresponding author: H.L. Fideleff, MD, PhD.,


Published Online: 2010-09-17

Published in Print: 2010-08-01


Citation Information: Journal of Pediatric Endocrinology and Metabolism, Volume 23, Issue 8, Pages 759–764, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: https://doi.org/10.1515/jpem.2010.125.

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Ibrahim Önsesveren, Mirjana Barjaktarovic, Layal Chaker, Yolanda B. de Rijke, Vincent W.V. Jaddoe, Hanneke M. van Santen, Theo J. Visser, Robin P. Peeters, and Tim I.M. Korevaar
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