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Roth, Christian

Journal of Pediatric Endocrinology and Metabolism

Editor-in-Chief: Kiess, Wieland

Ed. by Bereket, Abdullah / Cohen, Pinhas / Darendeliler, Feyza / Dattani, Mehul / Gustafsson, Jan / Luo, Feihong / Mericq, Veronica / Toppari, Jorma

Editorial Board Member: Battelino, Tadej / Buyukgebiz, Atilla / Cassorla, Fernando / Chrousos, George P. / Cutfield, Wayne / Fideleff, Hugo L. / Hershkovitz, Eli / Hiort, Olaf / LaFranchi, Stephen H. / Lanes M. D., Roberto / Mohn, Angelika / Root, Allen W. / Rosenfeld, Ron G. / Werther, George / Zadik, Zvi

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Volume 23, Issue 8 (Jan 2010)


Mean Platelet Volume in Obese Adolescents with Nonalcoholic Fatty Liver Disease

Nur Arslan
  • Corresponding author
  • Division of Gastroenterology and Nutrition, Dokuz Eylul University Hospital, Department of Pediatrics, Balçova, Izmir, Turkey
/ Balahan Makay
  • Division of Immunology and Rheumatology, Dokuz Eylul University Hospital, Department of Pediatrics, Balçova, Izmir, Turkey
Published Online: 2010-09-17 | DOI: https://doi.org/10.1515/jpem.2010.130


Background: Nonalcoholic fatty liver disease (NAFLD) is the accumulation of excess fat in the liver in the absence of alcohol consumption, which commonly coexists with obesity. NAFLD is associated with increased risk of atherosclerosis and insulin resistance Mean platelet volume (MPV) is a marker of platelet activation, which is a determinant of atherosclerosis.

Aims: The first aim of the present study was to investigate the MPV levels in obese adolescents and compare the MPV levels in patients with and without NAFLD and also with healthy controls. The second aim of this study was to evaluate the relationship between IR and MPV.

Patients and Methods: Case records of 128 exogenous obese adolescents were retrospectively evaluated. Laboratory parameters were collected by using a computerized patient database. Insulin resistance was calculated by a homeostasis model assessment (HOMA-IR) index. Patients were divided into two groups: patients with NAFLD (Group 1) and patients without NAFLD (Group 2). Forty-seven healthy children constituted the control group.

Results: MPV was significantly higher in obese adolescents than their healthy peers. Group 1 had significantly higher MPV than group 2. HOMA-IR was significantly higher in group 1 than group 2. MPV was significantly higher in patients with IR than patients without IR. There was a positive correlation between MPV and HOMA-IR. MPV was inversely correlated with HDL cholesterol and platelet count.

Conclusion: MPV may be used as a follow-up marker in patients with NAFLD at the point of atherosclerosis.

KEY WORDS: mean platelet volume; obesity; adolescents; nonalcoholic fatty liver disease; atherosclerosis; insulin resistance

About the article

Corresponding author: Nur Arslan, MD,

Published Online: 2010-09-17

Published in Print: 2010-08-01

Citation Information: Journal of Pediatric Endocrinology and Metabolism, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: https://doi.org/10.1515/jpem.2010.130.

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