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Roth, Christian

Journal of Pediatric Endocrinology and Metabolism

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Volume 23, Issue 9 (Jan 2010)


Bone Maturation in 1788 Children and Adolescents with Diabetes Mellitus Type 1

Axel Dost
  • Corresponding author
  • Department of Pediatrics, University of Jena, Germany
/ Tilman Rohrer
  • Department of Pediatrics, University of Homburg, Germany
/ Jörg Fussenegger
  • Children's Hospitals Dornbirn, Germany
/ Christian Vogel
  • Children's Hospitals Chemnitz, Germany
/ Bernd Schenk
  • Children's Hospitals Helios Klinikum Schwerin, Germany
/ Martin Wabitsch
  • Department of Pediatrics, University of Ulm, Germany
/ Beate Karges
  • RWTH Aachen University, Germany
/ Claudia Vilser
  • Department of Pediatrics, University of Jena, Germany
/ Reinhard W. Holl
  • University of Ulm, Germany
Published Online: 2010-12-22 | DOI: https://doi.org/10.1515/jpem.2010.144


Diabetes mellitus type 1 might interfere with pubertal development. Particularly, longterm metabolic control and intensity of insulin treatment have been reported to contribute to a delay in pubertal onset. Data on somatic development in diabetic children are conflicting; therefore we studied bone age in 1788 children from Germany and Austria with type 1 diabetes. Bone age was retarded by -0.27 ± 1.1 years in the whole group, but particularly in the adolescents at the end of puberty (>16 years; -0.76±1.29y). Bone age delay was more pronounced in boys, and in children with longterm median HbA1c levels of 7.5 – 9.0%. No associations were found with current HbA1c levels or the intensity of insulin treatment. Bone age determinations in diabetic children should only be performed when clinical signs of impaired somatic development are present. In addition, the potential influence of diabetes on bone development needs to be considered in the interpretation of carpograms.

KEY WORDS: auxiology; bone age determination; diabetes mellitus

About the article

Corresponding author: Dr. Axel Dost, MD,

Published Online: 2010-12-22

Published in Print: 2010-09-01

Citation Information: Journal of Pediatric Endocrinology and Metabolism, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: https://doi.org/10.1515/jpem.2010.144. Export Citation

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