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Roth, Christian

Journal of Pediatric Endocrinology and Metabolism

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Volume 24, Issue 1-2 (Mar 2011)


Vitamin D deficiency and insulin resistance in obese African- American adolescents

Gail Nunlee-Bland
  • Division of Endocrinology, Howard University, Washington, DC, USA
/ Kanwal Gambhir
  • Division of Endocrinology, Howard University, Washington, DC, USA
/ Cynthia Abrams
  • Department of Biochemistry and Molecular Biology, Howard University, Washington, DC, USA
/ Mustapha Abdul
  • Division of Endocrinology, Howard University, Washington, DC, USA
/ Marjan Vahedi
  • Division of Endocrinology, Howard University, Washington, DC, USA
/ Wolali Odonkor
  • Division of Endocrinology, Howard University, Washington, DC, USA
Published Online: 2011-03-16 | DOI: https://doi.org/10.1515/jpem.2011.107


Objective: The study aim determined if low 25-hydroxy vitamin D levels correlated with low levels of adiponectin and insulin resistance in African American adolescents with body mass index ≥85th%.

Patients and methods: Fasting blood levels of adiponectin, 25-hydroxy vitamin D, insulin, glucose, lipid, leptin and glycosylated hemoglobin were measured in a total of 34 (19 study and 15 control) African American adolescents between the ages of 10 and 20 years. Nutritional vitamin D intake and body composition measurements were assessed. Insulin resistance was calculated using the homeostasis model assessment.

Results: Adiponectin, fasting insulin, glucose, leptin, triglycerides, HDL, and 25-hydroxy vitamin D levels all reached statistical significance in the group with body mass index ≥85th percentile when compared to the control population. There was no difference in vitamin D intake between the two groups.

Conclusions: Low vitamin D levels correlated with low adiponectin levels and obesity and insulin resistance.

Keywords: African-American; adiponectin; adolescents; insulin resistance; obesity; vitamin D

About the article

Corresponding author: Gail Nunlee-Bland, Howard University Hospital, 2041 Georgia Avenue NW, Washington, DC 20060, USA Phone: +202-865-3350, Fax: +202-865-3495

Published Online: 2011-03-16

Published in Print: 2011-03-01

Citation Information: Journal of Pediatric Endocrinology and Metabolism, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: https://doi.org/10.1515/jpem.2011.107. Export Citation

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