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Roth, Christian

Journal of Pediatric Endocrinology and Metabolism

Editor-in-Chief: Kiess, Wieland

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Retinol binding protein 4 is associated with adiposity-related co-morbidity risk factors in children

Rushika Conroy
  • Pediatrics, New York Presbyterian Hospital-Columbia University Medical Center, New York, NY, USA
  • :
/ Yomery Espinal
  • Pediatrics, New York Presbyterian Hospital-Columbia University Medical Center, New York, NY, USA
/ Ilene Fennoy
  • Pediatrics, New York Presbyterian Hospital-Columbia University Medical Center, New York, NY, USA
/ Siham Accacha
  • Pediatrics, Winthrop University Hospital, Mineola, NY, USA
/ Claudia Boucher-Berry
  • Pediatrics, Cohen Children’s Medical Center, New Hyde Park, NY, USA
/ Dennis E. Carey
  • Pediatrics, Cohen Children’s Medical Center, New Hyde Park, NY, USA
/ Sharron Close
  • Pediatrics, New York Presbyterian Hospital-Columbia University Medical Center, New York, NY, USA
/ Deborah DeSantis
  • Pediatrics, Maimonides Infants and Children’s Hospital, Brooklyn, NY, USA
/ Rishi Gupta
  • Pediatrics, Winthrop University Hospital, Mineola, NY, USA
/ Abeer A. Hassoun
  • Pediatrics, New York Presbyterian Hospital-Columbia University Medical Center, New York, NY, USA
/ Loretta Iazzetti
  • Pediatrics, Cohen Children’s Medical Center, New Hyde Park, NY, USA
/ Fabean J. Jacques
  • Pediatrics, Winthrop University Hospital, Mineola, NY, USA
/ Amy M. Jean
  • Pediatrics, New York Presbyterian Hospital-Columbia University Medical Center, New York, NY, USA
/ Lesly Michel
  • Pediatrics, Winthrop University Hospital, Mineola, NY, USA
/ Katherine Pavlovich
  • Pediatrics, New York Presbyterian Hospital-Columbia University Medical Center, New York, NY, USA
/ Robert Rapaport
  • Pediatrics, Mount Sinai Medical Center, New York, NY, USA
/ Warren Rosenfeld
  • Pediatrics, Winthrop University Hospital, Mineola, NY, USA
/ Elisabeth Shamoon
  • Pediatrics, New York Presbyterian Hospital-Columbia University Medical Center, New York, NY, USA
/ Steven Shelov
  • Pediatrics, Maimonides Infants and Children’s Hospital, Brooklyn, NY, USA
/ Phyllis W. Speiser
  • Pediatrics, Cohen Children’s Medical Center, New Hyde Park, NY, USA
/ Svetlana Ten
  • Pediatrics, Maimonides Infants and Children’s Hospital, Brooklyn, NY, USA
/ Michael Rosenbaum
  • Pediatrics, New York Presbyterian Hospital-Columbia University Medical Center, New York, NY, USA
Published Online: 2011-11-01 | DOI: https://doi.org/10.1515/JPEM.2011.297

Abstract

Objective: In adults, elevated levels of retinol binding protein 4 (RBP4) have been associated with biochemical markers of adiposity-related co-morbidities including insulin resistance, dyslipidemia, hypertension, and abdominal obesity. This study examined the relationship between RBP4 and risk factors for co-morbidities of adiposity in a population of ethnically diverse children in early- to mid-adolescence in the public school system of New York City.

Materials/methods: We analyzed anthropometric (body mass index, % body fat, waist circumference), metabolic (lipids, glucose), and inflammatory (TNF-α, interleukin-6, C-reactive protein, adiponectin) markers for adiposity-related co-morbidities and serum alanine aminotransferase (ALT) in 106 school children (65 males, 41 females) 11–15 years of age (mean±SD=13.0±0.1 years) who were enrolled in the Reduce Obesity and Diabetes (ROAD) project. Insulin sensitivity was assessed by quantitative insulin sensitivity check index. Insulin secretory capacity was measured as acute insulin response and glucose disposal index.

Results: Serum RBP4 was significantly correlated directly with ALT, triglycerides, and triglyceride z-score, and inversely correlated with adiponectin. Correlations with ALT and adiponectin remained significant when corrected for % body fat, age, and gender. There were significant ethnic differences in the relationship of RBP4 to ALT, glucose disposal index and adiponectin.

Conclusions: In early- to mid-adolescents, circulating concentrations of RBP4 are correlated with multiple risk factors for adiposity-related co-morbidities. The observation that many associations persisted when corrected for % body fat, suggests that RBP4 can be viewed as an independent marker of adiposity-related co-morbidity risk in children.

Keywords: inflammation; insulin resistance; lipids; obesity

Corresponding author: Rushika Conroy, MD MS, Division of Pediatric Endocrinology, Children’s Hospital of New York, Presbyterian-Columbia University Medical Center, 622 West 168th Street, PH 5E-522, New York, NY 10032, USA Phone: +1-212-305-6559, Fax: +1-212-305-4778


Received: 2011-06-03

Accepted: 2011-08-19

Published Online: 2011-11-01

Published in Print: 2011-12-01


Citation Information: Journal of Pediatric Endocrinology and Metabolism. Volume 24, Issue 11-12, Pages 913–919, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: https://doi.org/10.1515/JPEM.2011.297, November 2011

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