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Roth, Christian

Journal of Pediatric Endocrinology and Metabolism

Editor-in-Chief: Kiess, Wieland

Ed. by Bereket, Abdullah / Cohen, Pinhas / Darendeliler, Feyza / Dattani, Mehul / Gustafsson, Jan / Luo, Feihong / Mericq, Veronica / Toppari, Jorma

Editorial Board Member: Battelino, Tadej / Buyukgebiz, Atilla / Cassorla, Fernando / Chrousos, George P. / Cutfield, Wayne / Fideleff, Hugo L. / Hershkovitz, Eli / Hiort, Olaf / LaFranchi, Stephen H. / Lanes M. D., Roberto / Mohn, Angelika / Root, Allen W. / Rosenfeld, Ron G. / Werther, George / Zadik, Zvi

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Congestive heart failure as an initial manifestation of reninoma

Min Jung Cho1 / Eun Young Sung2 / Ji Ae Park3 / 3

1Department of Pediatrics, Pusan National University Hospital, Busan, Republic of Korea

2Department of Nephrology, Pusan National University Hospital, Busan, Republic of Korea

3Department of Pediatrics, Pusan National University Children’s Hospital, Busan, Republic of Korea

Corresponding author: Hyoung Doo Lee, MD, PhD, Department of Pediatrics, Pusan National University Children’s Hospital, Beomeu-li, Mulgum-eup, Yangsan, Keungsangnam-do, Busan 626-770, Republic of Korea Phone: +82 55 360 3600

Citation Information: Journal of Pediatric Endocrinology and Metabolism. Volume 24, Issue 11-12, Pages 1085–1087, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: https://doi.org/10.1515/JPEM.2011.299, November 2011

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Reninoma or juxtaglomerular cell tumor (JCT) of the kidney is a rare but curable cause of severe hypertension. We report a case of reninoma in an 18-year-old woman. Interestingly, she initially presented with dilated cardiomyopathy, without any relevant history or signs of hypertension. Malignant hypertension, one of the cardinal signs of JCT, did not become apparent in the patient until several months later. Following a thorough evaluation, we detected a small mass in the left renal cortex as well as elevated plasma renin activity, which suggested the presence of a renin-producing tumor in the kidney. The patient’s blood pressure and plasma renin activity rapidly declined after a successful laparoscopic partial nephrectomy. We postulate that hyperreninemic-hyperaldosteronism followed by fluid retention caused a sudden severe increase in ventricular afterload and subsequent congestive heart failure in this patient.

Keywords: aldosterone; cardiac failure; hypertension; juxtaglomerular cell tumor; renin

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