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Roth, Christian

Journal of Pediatric Endocrinology and Metabolism

Editor-in-Chief: Kiess, Wieland

Ed. by Bereket, Abdullah / Cohen, Pinhas / Darendeliler, Feyza / Dattani, Mehul / Gustafsson, Jan / Luo, Feihong / Mericq, Veronica / Toppari, Jorma

Editorial Board Member: Battelino, Tadej / Buyukgebiz, Atilla / Cassorla, Fernando / Chrousos, George P. / Cutfield, Wayne / Fideleff, Hugo L. / Hershkovitz, Eli / Hiort, Olaf / LaFranchi, Stephen H. / Lanes M. D., Roberto / Mohn, Angelika / Root, Allen W. / Rosenfeld, Ron G. / Werther, George / Zadik, Zvi

IMPACT FACTOR 2015: 0.912

SCImago Journal Rank (SJR) 2015: 0.493
Source Normalized Impact per Paper (SNIP) 2015: 0.600
Impact per Publication (IPP) 2015: 0.955

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Peptides from adipose tissue in monitoring energy balance in infants

1 / Andrzej Wędrychowicz2 / Iwona Rogatko1 / Krzysztof Fyderek2 / Krystyna Sztefko1

1Department of Clinical Biochemistry, Gastroenterology and Nutrition, Jagiellonian University College of Medicine, Jagiellonian University, Krakow, Poland

2Department of Pediatrics, Gastroenterology and Nutrition, Jagiellonian University College of Medicine, Jagiellonian University, Krakow, Poland

Corresponding author: Przemyslaw J. Tomasik, Department of Clinical Biochemistry, Polish-American Children’s Hospital, Jagiellonian University, Wielicka St. 265, 30-663 Krakow, Poland Phone/Fax: +48 126580681

Citation Information: Journal of Pediatric Endocrinology and Metabolism. Volume 24, Issue 11-12, Pages 939–943, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: https://doi.org/10.1515/JPEM.2011.328, November 2011

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Background/aim: Overnutrition as well as undernutrition is a serious problem in hospitalized patients, especially in infants. Routine laboratory tests detecting disturbances in energy balance are not specific or accurate. The aim of this study was to evaluate adiponectin and leptin as markers of short-time energy malnutrition.

Methods: Forty-five infants fed orally and parenterally were included in the study. Plasma glucose, leptin and adiponectin were measured in a fasting state and postprandially (1 h after the meal), after a minimum of 24 h of total parenteral nutrition (TPN) and after a minimum of 8 h of intravenous infusion of glucose and crystalloids.

Results: Postprandial glucose levels in children fed orally was similar to that observed in children who received intravenous infusion of glucose. The TPN children had slightly higher glucose concentration in contrast to leptin levels which were significantly lower in this group (1.08 mg/mL±0.43) as compared to the others (p<0.05 in both cases). The mean postprandial levels of the adiponectin in orally fed children were significantly higher (10.7 μg/mL±2.4) than in children with TPN (5.8 μg/mL±2.4; p<0.001) and in children hydrated intravenously (3.3 μg/mL±2.3; p<0.001). The concentration of adiponectin correlated significantly with calorie intake.

Conclusions: Oral meal does not affect the plasma concentrations of leptin and adiponectin in infants. Adiponectin is a good short-time marker of energy malnutrition in infants.

Keywords: adiponectin; formula feeding infants; leptin; total parenteral nutrition

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