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Roth, Christian

Journal of Pediatric Endocrinology and Metabolism

Editor-in-Chief: Kiess, Wieland

Ed. by Bereket, Abdullah / Cohen, Pinhas / Darendeliler, Feyza / Dattani, Mehul / Gustafsson, Jan / Luo, Feihong / Mericq, Veronica / Toppari, Jorma

Editorial Board Member: Battelino, Tadej / Buyukgebiz, Atilla / Cassorla, Fernando / Chrousos, George P. / Cutfield, Wayne / Fideleff, Hugo L. / Hershkovitz, Eli / Hiort, Olaf / LaFranchi, Stephen H. / Lanes M. D., Roberto / Mohn, Angelika / Root, Allen W. / Rosenfeld, Ron G. / Werther, George / Zadik, Zvi

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IMPACT FACTOR 2016: 1.233

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2191-0251
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Volume 24, Issue 11-12 (Dec 2011)

Issues

Common adipokine features of neonates and centenarians

Cristina Meazza
  • Dipartimento di Scienze Pediatriche e Patologia Umana ed Ereditaria, Università di Pavia, Fondazione IRCCS San Matteo, Pavia, Italy
/ Giovanni Vitale
  • Dipartimento di Scienze Mediche, Università degli Studi di Milano, Milan, Italy
  • IRCCS Istituto Auxologico Italiano, Milan, Italy
/ Sara Pagani
  • Dipartimento di Scienze Pediatriche e Patologia Umana ed Ereditaria, Università di Pavia, Fondazione IRCCS San Matteo, Pavia, Italy
/ Davide Castaldi
  • Dipartimento di Informatica, Sistemistica e Comunicazione (DISCo), Universita’ degli Studi di Milano Bicocca, Milan, Italy
/ Giulia Ogliari
  • Dipartimento di Scienze Mediche, Università degli Studi di Milano, Milan, Italy
/ Daniela Mari
  • Dipartimento di Scienze Mediche, Università degli Studi di Milano, Milan, Italy
  • IRCCS Ca’ Granda Foundation Maggiore Policlinico Hospital, Milan, Italy
/ Kamilia Laarej
  • Unità di Epidemiologia Clinica e Biometria, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
/ Carmine Tinelli
  • Unità di Epidemiologia Clinica e Biometria, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
/ Mauro Bozzola
  • Dipartimento di Scienze Pediatriche e Patologia Umana ed Ereditaria, Università di Pavia, Fondazione IRCCS San Matteo, Pavia, Italy
  • Email:
Published Online: 2011-11-18 | DOI: https://doi.org/10.1515/JPEM.2011.373

Abstract

Adipose tissue seems to be a pivotal organ in the aging process. We investigated whether healthy aging could have its roots in a sound metabolic condition from the first year of life by evaluating leptin and adiponectin levels in neonates [33 adequate for gestational age (AGA) and 29 small for gestational age (SGA)], 48 centenarians, and 50 healthy elderly subjects. At birth, SGA neonates showed lower leptin levels (SGA 0.88±0.28; AGA 2.22±0.91 ng/mL; p<0.05) and comparable adiponectin levels with respect to AGA. At 1 year, SGA showed increased leptin (SGA 1.74±0.28; AGA 1.31±0.19 ng/mL) and slightly reduced adiponectin concentrations (SGA 35.51±2.53; AGA 38.56±3.18 μg/mL) than AGA. Centenarians showed lower leptin (centenarians 18.71±3.78; elderly 34.81±7.27 ng/mL; p<0.05) and higher adiponectin levels (centenarians 55.63±7.7; elderly 33.51±4.1 μg/mL; p<0.05) than elderly subjects. Centenarians, like AGA infants during the first year of life, show a favorable adipokine profile, suggesting that the metabolic condition at early age could affect the longevity of an individual.

Keywords: adiponectin; centenarians; leptin; small for gestational age

About the article

Corresponding author: Mauro Bozzola, MD, Dipartimento di Scienze Pediatriche, Università di Pavia, Fondazione IRCCS San Matteo, Piazzale C. Golgi 2, 27100 Pavia, Italy Phone: +39 382 502891, Fax +39 382 527976


Received: 2011-08-01

Accepted: 2011-10-24

Published Online: 2011-11-18

Published in Print: 2011-12-01


Citation Information: Journal of Pediatric Endocrinology and Metabolism, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: https://doi.org/10.1515/JPEM.2011.373.

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