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Journal of Pediatric Endocrinology and Metabolism

Editor-in-Chief: Kiess, Wieland

Ed. by Bereket, Abdullah / Cohen, Pinhas / Darendeliler, Feyza / Dattani, Mehul / Gustafsson, Jan / Luo, Feihong / Mericq, Veronica / Roth, Christian / Toppari, Jorma

Editorial Board Member: Battelino, Tadej / Buyukgebiz, Atilla / Cassorla, Fernando / Chrousos, George P. / Cutfield, Wayne / Fideleff, Hugo L. / Hershkovitz, Eli / Hiort, Olaf / LaFranchi, Stephen H. / Lanes M. D., Roberto / Mohn, Angelika / Root, Allen W. / Rosenfeld, Ron G. / Werther, George / Zadik, Zvi

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Common adipokine features of neonates and centenarians

Cristina Meazza1 / Giovanni Vitale2, 3 / Sara Pagani1 / Davide Castaldi4 / Giulia Ogliari2 / Daniela Mari2, 5 / Kamilia Laarej1 / Carmine Tinelli6 / 1

1Dipartimento di Scienze Pediatriche e Patologia Umana ed Ereditaria, Università di Pavia, Fondazione IRCCS San Matteo, Pavia, Italy

2Dipartimento di Scienze Mediche, Università degli Studi di Milano, Milan, Italy

3IRCCS Istituto Auxologico Italiano, Milan, Italy

4Dipartimento di Informatica, Sistemistica e Comunicazione (DISCo), Universita’ degli Studi di Milano Bicocca, Milan, Italy

5IRCCS Ca’ Granda Foundation Maggiore Policlinico Hospital, Milan, Italy

6Unità di Epidemiologia Clinica e Biometria, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy

Corresponding author: Mauro Bozzola, MD, Dipartimento di Scienze Pediatriche, Università di Pavia, Fondazione IRCCS San Matteo, Piazzale C. Golgi 2, 27100 Pavia, Italy Phone: +39 382 502891, Fax +39 382 527976

Citation Information: Journal of Pediatric Endocrinology and Metabolism. Volume 24, Issue 11-12, Pages 953–957, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: 10.1515/JPEM.2011.373, November 2011

Publication History

Published Online:


Adipose tissue seems to be a pivotal organ in the aging process. We investigated whether healthy aging could have its roots in a sound metabolic condition from the first year of life by evaluating leptin and adiponectin levels in neonates [33 adequate for gestational age (AGA) and 29 small for gestational age (SGA)], 48 centenarians, and 50 healthy elderly subjects. At birth, SGA neonates showed lower leptin levels (SGA 0.88±0.28; AGA 2.22±0.91 ng/mL; p<0.05) and comparable adiponectin levels with respect to AGA. At 1 year, SGA showed increased leptin (SGA 1.74±0.28; AGA 1.31±0.19 ng/mL) and slightly reduced adiponectin concentrations (SGA 35.51±2.53; AGA 38.56±3.18 μg/mL) than AGA. Centenarians showed lower leptin (centenarians 18.71±3.78; elderly 34.81±7.27 ng/mL; p<0.05) and higher adiponectin levels (centenarians 55.63±7.7; elderly 33.51±4.1 μg/mL; p<0.05) than elderly subjects. Centenarians, like AGA infants during the first year of life, show a favorable adipokine profile, suggesting that the metabolic condition at early age could affect the longevity of an individual.

Keywords: adiponectin; centenarians; leptin; small for gestational age

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