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Roth, Christian

Journal of Pediatric Endocrinology and Metabolism

Editor-in-Chief: Kiess, Wieland

Ed. by Bereket, Abdullah / Cohen, Pinhas / Darendeliler, Feyza / Dattani, Mehul / Gustafsson, Jan / Luo, Feihong / Mericq, Veronica / Toppari, Jorma

Editorial Board Member: Battelino, Tadej / Buyukgebiz, Atilla / Cassorla, Fernando / Chrousos, George P. / Cutfield, Wayne / Fideleff, Hugo L. / Hershkovitz, Eli / Hiort, Olaf / LaFranchi, Stephen H. / Lanes M. D., Roberto / Mohn, Angelika / Root, Allen W. / Rosenfeld, Ron G. / Werther, George / Zadik, Zvi

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Gender differences exist in the association of leptin and adiponectin levels with insulin resistance parameters in prepubertal Arab children

1, 2 / Omar S. Al-Attas1, 2 / Majed S. Alokail1, 2 / Khalid M. Alkharfy1–3, , / Tajamul Hussain2 / Shaun Sabico1

1Biomarkers Research Program, Department of Biochemistry, College of Science, King Saud University, Riyadh, Saudi Arabia

2Centre of Excellence in Biotechnology Research, King Saud University, Riyadh, Saudi Arabia

3Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia

Corresponding author: Nasser M. Al-Daghri, Department of Biochemistry, P.O. Box 2455, College of Science, King Saud University, Riyadh 11451, Saudi Arabia Phone: +966-014675939, Fax: +966-014675931

Citation Information: Journal of Pediatric Endocrinology and Metabolism. Volume 24, Issue 7-8, Pages 427–432, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: https://doi.org/10.1515/jpem.2011.246, August 2011


Aim: Differences in correlations between leptin, adiponectin and insulin resistance in children exist in different ethnic populations. No such information is available in Arab children. This study aims to fill this gap.

Methods: Three hundred and twenty-five prepubertal children were recruited in this cross-sectional study. Body mass index (BMI), waist and hip circumferences and fasting glucose were measured by standard procedures. Serum insulin, leptin and adiponectin were assayed by ELISA.

Results: Leptin and adiponectin levels were significantly correlated with anthropometric parameters, HOMA-IR and insulin in all subjects and with fasting glucose in girls only. Correlations of adiponectin with HOMA-IR and insulin in boys and of leptin with insulin in girls were independent of BMI, waist and hip circumferences.

Conclusion: Gender differences exist in the distribution of adipocytokines in prepubertal children. The associations of adipocytokines with obesity biomarkers in prepubertal children suggest a causal link between childhood obesity and the risk of an early diabetes onset.

Keywords: adiponectin; childhood obesity; insulin resistance; leptin

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