Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Journal of Pediatric Endocrinology and Metabolism

Editor-in-Chief: Kiess, Wieland

Ed. by Bereket, Abdullah / Darendeliler, Feyza / Dattani, Mehul / Gustafsson, Jan / Luo, Fei Hong / Mericq, Veronica / Toppari, Jorma


IMPACT FACTOR 2018: 1.239

CiteScore 2018: 1.22

SCImago Journal Rank (SJR) 2018: 0.507
Source Normalized Impact per Paper (SNIP) 2018: 0.562

Online
ISSN
2191-0251
See all formats and pricing
More options …
Volume 24, Issue 7-8

Issues

Ovarian function in adolescents with McCune-Albright syndrome

Karina Sotomayor
  • Institute of Maternal and Child Research, University of Chile, Hospital San Borja Arriaran, Santiago, Chile
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ German Iñiguez
  • Institute of Maternal and Child Research, University of Chile, Hospital San Borja Arriaran, Santiago, Chile
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Francisca Ugarte / Claudio Villarroel
  • Institute of Maternal and Child Research, University of Chile, Hospital San Borja Arriaran, Santiago, Chile
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Patricia López
  • Institute of Maternal and Child Research, University of Chile, Hospital San Borja Arriaran, Santiago, Chile
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Alejandra Avila
  • Institute of Maternal and Child Research, University of Chile, Hospital San Borja Arriaran, Santiago, Chile
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Ethel Codner
  • Institute of Maternal and Child Research, University of Chile, Hospital San Borja Arriaran, Santiago, Chile
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Fernando Cassorla

Abstract

Objective: To evaluate ovarian function, especially ovulation rate, in adolescents with McCune-Albright syndrome (MAS) and a history of peripheral precocious puberty.

Design: Prospective cross-sectional study.

Setting: Academic center.

Patient(s): A total of eight adolescents with MAS were compared with 15 healthy adolescents matched by age, Tanner stage and body mass index.

Intervention(s): We determined basal gonadotropins, sex steroids, sex hormone binding globulin, anti-Müllerian hormone, glucose and insulin. A leuprolide acetate test was performed to measure luteinizing hormone (LH) and follicle stimulating hormone (FSH) (at 0 and 3 h), and 17B-estradiol, testosterone and 17-OH-progesterone (at 0 and 24 h). Salivary progesterone levels were used to assess ovulation during the 13th, 18th, 23rd and 28th days of each menstrual cycle for three to five consecutive cycles, and one pelvic ultrasound was performed during the follicular phase.

Main outcome measure(s): Ovulation rate in adolescents with MAS.

Result(s): The proportion of ovulatory cycles was 52.6% in controls compared with 35.7% in patients with MAS.

Conclusion(s): The adolescent girls with MAS appear to have a lower ovulatory rate compared with controls.

Keywords: McCune-Albright syndrome; ovarian function; ovulatory rate; puberty

About the article

Corresponding author: Fernando Cassorla, MD, Casilla 223-6, Santiago, Chile Phone: +56-2-977-0850, Fax: +56-2-424-7240


Published in Print: 2011-08-01


Citation Information: Journal of Pediatric Endocrinology and Metabolism, Volume 24, Issue 7-8, Pages 525–528, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: https://doi.org/10.1515/jpem.2011.265.

Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
Domenico Corica, Tommaso Aversa, Giorgia Pepe, Filippo De Luca, and Malgorzata Wasniewska
Frontiers in Endocrinology, 2018, Volume 9
[2]
Laura Gaspari, Françoise Paris, Marc Nicolino, Frédéric Hameury, Hélène Bonnaure, Catherine Pienkowski, Nadège Servant, Nicolas Kalfa, and Charles Sultan
Prenatal Diagnosis, 2012, Page 1

Comments (0)

Please log in or register to comment.
Log in