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Journal of Pediatric Endocrinology and Metabolism

Editor-in-Chief: Kiess, Wieland

Ed. by Bereket, Abdullah / Darendeliler, Feyza / Dattani, Mehul / Gustafsson, Jan / Luo, Fei Hong / Mericq, Veronica / Ogata, Tsutomu / Toppari, Jorma

12 Issues per year

IMPACT FACTOR 2017: 1.086

CiteScore 2017: 1.07

SCImago Journal Rank (SJR) 2017: 0.465
Source Normalized Impact per Paper (SNIP) 2017: 0.580

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Volume 24, Issue 9-10


Multivariate analyses of factors that affect neonatal screening thyroid stimulating hormone

Sze May Ng / Sze Choong Wong / Fauzia Paize / Elavazhagan Chakkarapani / Paul Newland / David Isherwood / Mohammed Didi
Published Online: 2011-08-25 | DOI: https://doi.org/10.1515/JPEM.2011.234


Aims: All screening programmes in the UK use a primary thyroid stimulating hormone (TSH) screen for congenital hypothyroidism. Recent attention has been paid to aspects of screening, such as the relation between blood spot TSH levels and birth weight or gestational age. The aim of our study was to determine the factors affecting screening neonatal TSH levels.

Methods: We conducted a retrospective analysis of blood spot screening TSH levels of all infants screened at a single regional screening laboratory.

Results: There were 6498 infants screened during a 12-week period. Screening TSH level showed negative correlation with gestational age and birth weight. Multiple linear regression analysis revealed low birth weight as the only independent factor affecting screening TSH level.

Conclusions: Low birth weight infants appear to be at risk of thyroidal dysfunction. Our study showed that there were clinically significant but weak correlation between higher screening TSH levels and low birth weight. The clinical importance of these findings requires larger prospective studies to further elucidate the relevance of these factors affecting TSH screening levels.

Keywords: birth weight; congenital hypothyroidism; gestation; screening; thyroid stimulating hormone (TSH)

About the article

Corresponding author: Dr. Sze May Ng, Paediatrics Department, Southport and Ormskirk Hospital, Wigan Road, Ormskirk L39 2AZ, UK Phone: +44 01695 656163, Fax: +44 01695 656282

Received: 2011-03-29

Accepted: 2011-07-16

Published Online: 2011-08-25

Published in Print: 2011-10-01

Citation Information: Journal of Pediatric Endocrinology and Metabolism, Volume 24, Issue 9-10, Pages 727–732, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: https://doi.org/10.1515/JPEM.2011.234.

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