Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Journal of Pediatric Endocrinology and Metabolism

Editor-in-Chief: Kiess, Wieland

Ed. by Bereket, Abdullah / Darendeliler, Feyza / Dattani, Mehul / Gustafsson, Jan / Luo, Feihong / Mericq, Veronica / Roth, Christian / Toppari, Jorma

Editorial Board: Battelino, Tadej / Buyukgebiz, Atilla / Cassorla, Fernando / Chrousos, George P. / Cutfield, Wayne / Fideleff, Hugo L. / Hershkovitz, Eli / Hiort, Olaf / LaFranchi, Stephen H. / Lanes M. D., Roberto / Mohn, Angelika / Root, Allen W. / Rosenfeld, Ron G. / Werther, George / Zadik, Zvi

12 Issues per year


IMPACT FACTOR 2016: 1.233

CiteScore 2016: 1.09

SCImago Journal Rank (SJR) 2016: 0.527
Source Normalized Impact per Paper (SNIP) 2016: 0.602

Online
ISSN
2191-0251
See all formats and pricing
More options …
Volume 25, Issue 1-2

Issues

Encephalopathy and sinustachycardia in childhood a possible differential diagnosis

Tobias Hecht / Jörg Brand / Stefan Vlaho
Published Online: 2012-01-17 | DOI: https://doi.org/10.1515/jpem-2011-0436

Abstract

We report on a 7-year-old girl with generalized seizures, somnolence, fever, and respiratory distress. The increase of sinus tachycardia with good hydration, sufficient analgesia, and hyperthermia in our patient led to the determination of thyroid hormones, and therefore finally to the diagnosis of a thyrotoxic crisis in Graves’ disease. Thyrotoxic crisis is a very rare but severe disease with an incidence of 0.1/100,000–3/100,000 among children. Important differential diagnoses of hyperthyroidism are Hashimoto thyroiditis, paraneoplastic thyroid-stimulating hormone production, thyroid autonomy, as well as central hyperthyroidism. Although symptoms disappear by thyrostatic therapy (thiamazole, carbimazole, dexamethasone), a euthyroid status could only be achieved by thyroidectomy. Thyrotoxic crisis should be considered a differential diagnosis in case of resistant unexplained sinus tachycardia, seizures, and encephalopathy. Immediate and adequate therapy contributes significantly to a reduction in the high morbidity and mortality rates. A combination of several treatment approaches for hyperthyroidism can lead to a successful outcome.

Keywords: drug-resistant thyroid storm; encephalopathy; Graves’ disease; seizure; thyroidectomy

About the article

Corresponding author: Tobias Hecht, Intensive Care Unit, Children’s Hospital, Goethe University, Theodor Stern Kai 7, Frankfurt (Main) 60590, Germany


Received: 2011-10-20

Accepted: 2011-12-10

Published Online: 2012-01-17

Published in Print: 2012-02-01


Citation Information: Journal of Pediatric Endocrinology and Metabolism, Volume 25, Issue 1-2, Pages 149–151, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: https://doi.org/10.1515/jpem-2011-0436.

Export Citation

©2012 by Walter de Gruyter Berlin Boston. Copyright Clearance Center

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
Kanshi Minamitani, Hirokazu Sato, Hidemi Ohye, Shohei Harada, and Osamu Arisaka
Clinical Pediatric Endocrinology, 2017, Volume 26, Number 2, Page 29

Comments (0)

Please log in or register to comment.
Log in