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Roth, Christian

Journal of Pediatric Endocrinology and Metabolism

Editor-in-Chief: Kiess, Wieland

Ed. by Bereket, Abdullah / Cohen, Pinhas / Darendeliler, Feyza / Dattani, Mehul / Gustafsson, Jan / Luo, Feihong / Mericq, Veronica / Toppari, Jorma

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Serum chitotriosidase activity: is it a new inflammatory marker in obese children?

Ahmet Afsin Kundak
  • Dr. Sami Ulus Maternity and Children’s Hospital, Ankara, Turkey
  • :
/ Mehmet Emre Tascılar
  • Gulhane Military Medical Faculty, Department of Pediatrics, Ankara, Turkey
/ Ayhan Abaci
  • Gulhane Military Medical Faculty, Department of Pediatrics, Ankara, Turkey
/ Ilker Devrim
  • Gulhane Military Medical Faculty, Department of Pediatrics, Ankara, Turkey
/ Ilker Tolga Ozgen
  • Gulhane Military Medical Faculty, Department of Pediatrics, Ankara, Turkey
/ Ugur Demirpek
  • Gulhane Military Medical Faculty, Department of Biochemistry and Clinical Biochemistry, Ankara, Turkey
/ Ozlem Ozturk
  • Gulhane Military Medical Faculty, Department of Biochemistry and Clinical Biochemistry, Ankara, Turkey
/ Abdullah Olgun
  • Gulhane Military Medical Faculty, Department of Biochemistry and Clinical Biochemistry, Ankara, Turkey
/ Ismail Kurt
  • Gulhane Military Medical Faculty, Department of Biochemistry and Clinical Biochemistry, Ankara, Turkey
Published Online: 2011-12-08 | DOI: https://doi.org/10.1515/jpem.2011.329

Abstract

Chitotriosidase (ChT) is an enzyme secreted by activated macrophages and involved in defense against, and in degradation of chitin-containing pathogens, such as fungi, nematodes, and insects. In addition, it plays an important role in the development of atherosclerosis related with systemic low-grade inflammation. To this effect of activity of ChT, we aimed to investigate serum ChT activity in obese subjects and to determine to relation with insulin resistance and high-sensitive C-reactive protein (hsCRP). A total of 73 obese subjects (10.9±2.6 years of age, 44 male patients) and 41 age and gender-matched healthy lean subjects (11.6±2.9 years of age, 18 male patients) were included in this study, between 2007 and 2008. The criterion for diagnosing obesity was defined as the body mass index (BMI) being over 97th percentile of the same gender and age. Fasting serum glucose, insulin, hsCRP and ChT levels were measured. We compared the differences in variables between obese and lean subjects with Student’s t-test compared after ascertaining that the data were normally distributed. All data were expressed as mean±standard deviation. There was statistically significant increase in serum ChT activity of obese subjects, while there was statistically significant difference in serum hsCRP levels when compared to healthy lean subjects (30.0±17.9 and 23.0±17.8, p=0.045; 2.3±3.1 and 0.7±1.2, p=0.001). Obese subjects had significantly higher BMI-SDS, TG and HOMA-IR and lower HDL-C levels when compared with the healthy lean subjects (p<0.05). Correlation analysis showed no significant correlation between serum ChT activity and hsCRP, HOMA-IR and BMI-SDS (p>0.05). Although the data need to be validated by further investigation, the observations made in this study seem to indicate that serum ChT activity may not be a useful marker for monitoring systemic low-grade inflammation and insulin resistance in obese subjects.

Keywords: chitotriosidase activity; C-reactive protein; obesity

Corresponding author: Ahmet Afsin Kundak, Dr. Sami Ulus Kadın Dogum, Çocuk Saglıgı ve Hastalıkları EAH, Yenidogan Kliniği Babur Caddesi, No: 44 (06080), Altındag, Ankara, Turkey Phone: +312 305 6283, Fax: +312 317 0353


Received: 2011-06-28

Accepted: 2011-10-24

Published Online: 2011-12-08

Published in Print: 2012-02-01


Citation Information: Journal of Pediatric Endocrinology and Metabolism. Volume 25, Issue 1-2, Pages 63–67, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: https://doi.org/10.1515/jpem.2011.329, December 2011

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