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Journal of Pediatric Endocrinology and Metabolism

Editor-in-Chief: Kiess, Wieland

Ed. by Bereket, Abdullah / Cohen, Pinhas / Darendeliler, Feyza / Dattani, Mehul / Gustafsson, Jan / Luo, Feihong / Mericq, Veronica / Roth, Christian / Toppari, Jorma

Editorial Board Member: Battelino, Tadej / Buyukgebiz, Atilla / Cassorla, Fernando / Chrousos, George P. / Cutfield, Wayne / Fideleff, Hugo L. / Hershkovitz, Eli / Hiort, Olaf / LaFranchi, Stephen H. / Lanes M. D., Roberto / Mohn, Angelika / Root, Allen W. / Rosenfeld, Ron G. / Werther, George / Zadik, Zvi

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2191-0251
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Volume 25, Issue 11-12 (Dec 2012)

Issues

Acanthosis nigricans predicts the clustering of metabolic syndrome components in Hispanic elementary school-aged children

Alberta S. Kong / Laura Vanderbloemen / Betty Skipper
  • Family and Community Medicine, University of New Mexico School of Medicine, Albuquerque, NM, USA
  • Other articles by this author:
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/ John Leggott
  • Family and Community Medicine, University of New Mexico School of Medicine, Albuquerque, NM, USA
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/ Emilie Sebesta / Robert Glew
  • Department of Biochemistry and Molecular Biology, University of New Mexico School of Medicine, Albuquerque, NM, USA
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/ Mark R. Burge
  • Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, NM, USA
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Published Online: 2012-10-02 | DOI: https://doi.org/10.1515/jpem-2012-0117

Abstract

Background: Acanthosis nigricans (AN) is a dermatologic condition associated with hyperinsulinemia, a marker of insulin resistance that is the principal abnormality in metabolic syndrome (MetS). We examined the association of AN with the clustering of MetS components.

Methods: A cross-sectional study was conducted in an urban school-based health center in New Mexico. Students without diabetes were evaluated for AN, a family history of type 2 diabetes, body mass index (BMI), and MetS components. The clustering of MetS components by BMI category and AN status was assessed by comparing the group means of summed average z-scores of fasting insulin, triglycerides, high-density lipoprotein-cholesterol, and systolic blood pressure among the students. A multivariate model with BMI category and AN status controlling for Tanner stage was performed to identify the variables associated with the clustering of MetS components.

Results: Complete data were available for 90 children (age, 9.7±1.4 years; 94% Hispanic; 60% female). In multivariate modeling of MetS cluster z-score, significant differences were found between the students with BMI <85th percentile [–0.27; 95% confidence interval (95% CI)=–0.42 to –0.11] and (a) the students with BMI 85th–94.9th percentile with AN (0.74; 95% CI=0.17–1.31) and (b) the students with BMI ≥95th percentile with AN (0.86; 95% CI=0.54–1.18). No significant differences in the MetS cluster z-score were seen between the students with BMI <85th percentile and those with BMI 85th–94.9th percentile without AN (0.24; 95% CI=–0.33 to 0.81) or those with BMI ≥95th percentile without AN (0.31; 95% CI=–0.13 to 0.75).

Conclusions: Overweight/obese Hispanic elementary school-aged children with AN exhibit clustering of MetS components and could benefit from early intervention.

Keywords: Acanthosis nigricans; children; Hispanic; insulin resistance; metabolic syndrome; obesity; school health services

About the article

Corresponding author: Alberta S. Kong, MD, MPH, Department of Pediatrics, University of New Mexico School of Medicine, MSC 10 5590, Albuquerque, NM 87131-0001, USA, Phone: +(505) 272-4462, Fax: +(505) 272-6845


Received: 2012-04-12

Accepted: 2012-08-04

Published Online: 2012-10-02

Published in Print: 2012-12-01


Citation Information: Journal of Pediatric Endocrinology and Metabolism, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: https://doi.org/10.1515/jpem-2012-0117.

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©2012 by Walter de Gruyter Berlin Boston. Copyright Clearance Center

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