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Roth, Christian

Journal of Pediatric Endocrinology and Metabolism

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Volume 25, Issue 11-12 (Dec 2012)

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Increased endothelial microparticles in obese and overweight children

Zübeyde Gündüz
  • Faculty of Medicine, Department of Pediatric Nephrology, Erciyes University, Kayseri, Turkey
/ İsmail Dursun
  • Corresponding author
  • Faculty of Medicine, Department of Pediatric Nephrology, Erciyes University, Kayseri, Turkey
  • Email:
/ Sebahat Tülpar
  • Faculty of Medicine, Department of Pediatric Nephrology, Erciyes University, Kayseri, Turkey
/ Funda Baştuğ
  • Faculty of Medicine, Department of Pediatric Nephrology, Erciyes University, Kayseri, Turkey
/ Ali Baykan
  • Faculty of Medicine, Department of Pediatric Cardiology, Erciyes University, Kayseri, Turkey
/ Ali Yıkılmaz
  • Faculty of Medicine, Department of Pediatric Radiology, Erciyes University, Kayseri, Turkey
/ Türkan Patıroğlu
  • Faculty of Medicine, Department of Pediatric Immunology, Erciyes University, Kayseri, Turkey
/ Hakan M. Poyrazoglu
  • Faculty of Medicine, Department of Pediatric Nephrology, Erciyes University, Kayseri, Turkey
/ Leyla Akın
  • Faculty of Medicine, Department of Pediatric Endocrinology, Erciyes University, Kayseri, Turkey
/ Sibel Yel
  • Faculty of Medicine, Department of Pediatric Nephrology, Erciyes University, Kayseri, Turkey
/ Ruhan Düşünsel
  • Faculty of Medicine, Department of Pediatric Nephrology, Erciyes University, Kayseri, Turkey
Published Online: 2012-09-15 | DOI: https://doi.org/10.1515/jpem-2012-0194

Abstract

Background: Obesity in children increases the risk of atherosclerosis. Endothelial dysfunction is an important factor in the pathogenesis of atherosclerosis, and endothelial microparticles (EMPs) are considered as markers of endothelial dysfunction. In this study, we aimed to evaluate circulating EMPs in obese and overweight children and to disclose the measure of obesity with the strongest relation with circulating microparticles and carotid atherosclerosis.

Methods: This prospective study included 55 obese and overweight children and 23 healthy controls. Insulin resistance was studied. Both in vivo and in vitro human umbilical vein endothelial cell evaluations were used for the study. Circulating EMPs (CD144 and CD146) were measured by flow cytometry. The carotid artery intima-media thickness (cIMT) and left ventricular mass index (LVMI) were measured using ultrasound and echocardiography, respectively. Study groups were compared for anthropometric measurement, insulin resistance, circulating EMP, cIMT, and LVMI. The relationship among overweight, obesity, and circulating EMPs were investigated.

Results: Blood pressure, CD144+EMP levels, and LVMI were statistically higher in the patients group than in the control group. The multiple logistic regression analysis and the backward elimination method showed that CD144+EMP and systolic blood pressure had a linear relationship with overweight and obesity.

Conclusion: Our results suggest that endothelial damage starts in the early stage of childhood obesity and that obese and overweight children have increased circulating CD144+EMPs, showing that endothelial dysfunction and increased CD144+EMPs may be related to obesity.

Keywords: atherosclerosis; childhood obesity; endothelial microparticles; inflammation

About the article

Corresponding author: İsmail Dursun, MD, Faculty of Medicine, Department of Pediatric Nephrology, Erciyes University, 38039 Kayseri, Turkey, Phone: +90-352-4374937-25464, GSM: +90-505-9067145, Fax: +90-352-4375825


Received: 2012-06-19

Accepted: 2012-08-17

Published Online: 2012-09-15

Published in Print: 2012-12-01


Citation Information: Journal of Pediatric Endocrinology and Metabolism, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: https://doi.org/10.1515/jpem-2012-0194.

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©2012 by Walter de Gruyter Berlin Boston. Copyright Clearance Center

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